ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Stability of thalamocortical synaptic transmission across awake brain states.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 85 citations in OpenAlex.
- Deciphering neuronal variability across states reveals dynamic sensory encoding.Nature communications · 2025Article
- Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice.eLife · 2023Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spike Timing-Dependent Plasticity with Enhanced Long-Term Depression Leads to an Increase of Statistical Complexity.Entropy (Basel, Switzerland) · 2022Article
- Thalamic bursting and the role of timing and synchrony in thalamocortical signaling in the awake mouse.Neuron · 2022Article
- Thalamic state influences timing precision in the thalamocortical circuit.Journal of neurophysiology · 2021Article
- Modeling the Short-Term Dynamics ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Layer-Specific Physiological Features and Interlaminar Interactions in the Primary Visual Cortex of the Mouse.Neuron · 2019Article
- Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface.Journal of neural engineering · 2018Article
- Axonal Conduction Delays, Brain State, and Corticogeniculate Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Focal Local Field Potential Signature of the Single-Axon Monosynaptic Thalamocortical Connection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A novel method for classifying cortical state to identify the accompanying changes in cerebral hemodynamics.Journal of neuroscience methods · 2016Article
- Push-Pull Receptive Field Organization and Synaptic Depression: Mechanisms for Reliably Encoding Naturalistic Stimuli in V1.Frontiers in neural circuits · 2016Article
- Wideband phase locking to modulated whisker vibration point to a temporal code for texture in the rat's barrel cortex.Experimental brain research · 2015Article
- Hour-long adaptation in the awake early visual system.Journal of neurophysiology · 2015Article
- Optogenetic feedback control of neural activity.eLife · 2015Article
- Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays.Journal of neuroscience methods · 2015Article
- Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording.Biomaterials · 2015Article
- Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.Biomaterials · 2014Article
- Neuromodulators produce distinct activated states in neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sensory cortical neurons are highly sensitive to brain state, with many neurons showing changes in spatial and/or temporal response properties and some neurons becoming virtually unresponsive when subjects are not alert. Although some of these changes are undoubtedly attributable to state-related filtering at the thalamic level, another likely source of such effects is the thalamocortical (TC) synapse, where activation of nicotinic receptors on TC terminals have been shown to enhance synaptic transmission in vitro. However, monosynaptic TC synaptic transmission has not been directly examined during different states of alertness. Here, in awake rabbits that shifted between alert and non-alert EEG states, we examined the monosynaptic TC responses and short-term synaptic dynamics generated by spontaneous impulses of single visual and somatosensory TC neurons. We did this using spike-triggered current source-density analysis, an approach that enables assessment of monosynaptic extracellular currents generated in different cortical layers by impulses of single TC afferents. Spontaneous firing rates of TC neurons were higher, and burst rates were much lower in the alert state. However, we found no state-related changes in the amplitude of monosynaptic TC responses when TC spikes with similar preceding interspike interval were compared. Moreover, the relationship between the preceding interspike interval of the TC spike and postsynaptic response amplitude was not influenced by state. These data indicate that TC synaptic transmission and dynamics are highly conserved across different states of alertness and that observed state-related changes in receptive field properties that occur at the cortical level result from other mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.