ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Dopamine depletion induces distinct compensatory gene expression changes in DARPP-32 signal transduction cascades of striatonigral and striatopallidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice.Scientific reports · 2025Article
- Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes.Advances in neurobiology · 2024Review
- Levodopa-Induced Dyskinesia in Parkinson's Disease: Pathogenesis and Emerging Treatment Strategies.Cells · 2022Review
- Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates.Cell reports · 2018Article
- Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.Neuron · 2015Article
- Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice.Brain research · 2013Article
- Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Dopaminergic modulation of striatal neurons, circuits, and assemblies.Neuroscience · 2011Review
- Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Gene x disease interaction on orbitofrontal gray matter in cocaine addiction.Archives of general psychiatry · 2011Article
- Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments.Frontiers in neuroanatomy · 2011Article
- Unraveling the differential functions and regulation of striatal neuron sub-populations in motor control, reward, and motivational processes.Frontiers in behavioral neuroscience · 2011Article
- Modulation of striatal projection systems by dopamine.Annual review of neuroscience · 2011Review
- Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian rats.PloS one · 2010Article
- Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats.The European journal of neuroscience · 2010Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Functional alterations in striatal projection neurons play a critical role in the development of motor symptoms in Parkinson's disease (PD), but their molecular adaptation to dopamine depletion remains poorly understood. In particular, type and extent of regulation in postsynaptic signal transduction pathways that determine the responsiveness of striatal projection neurons to incoming stimuli, are currently unknown. Using cell-type-specific transcriptome analyses in a rodent model of chronic dopamine depletion, we identified large-scale gene expression changes, including neurotransmitter receptors, signal transduction cascades, and target proteins of dopamine signaling in striatonigral and striatopallidal neurons. Within the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) cascade of enzymes that plays a central role in signal integration of dopaminoceptive neurons multiple catalytic and regulatory subunits change their mRNA expression levels. In addition to the number of genes the fact that the alterations occur at multiple levels stresses the biological relevance of transcriptional regulation for adaptations of postsynaptic signaling pathways. The overall pattern of changes in both striatonigral and striatopallidal neurons is compatible with homeostatic mechanisms. In accordance with the distinct biological effects of dopamine D(1) and D(2) receptor stimulation, the alterations of the transcriptional profiles most likely result in prodopaminergic phosphorylation patterns. Our data provide insight into the disease-related plasticity of functional genomic networks in vivo that might contribute to the protracted preclinical phase of PD. In addition, the data have potential implications for the symptomatic treatment of the disease.
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