ArticleGenetics2009
Modeling multiallelic selection using a Moran model.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Joint estimation of selection intensity and mutation rate under balancing selection with applications to HLA.Genetics · 2022Article
- Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection.Molecular biology and evolution · 2020Article
- Invasion and Extinction Dynamics of Mating Types Under Facultative Sexual Reproduction.Genetics · 2019Article
- Statistical Inference in the Wright-Fisher Model Using Allele Frequency Data.Systematic biology · 2017Review
- Article
- Emergence of stable polymorphisms driven by evolutionary games between mutants.Nature communications · 2012Article
- The allele-frequency spectrum in a decoupled Moran model with mutation, drift, and directional selection, assuming small mutation rates.Theoretical population biology · 2012Article
- Reconstructing the dynamics of HIV evolution within hosts from serial deep sequence data.PLoS computational biology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a Moran-model approach to modeling general multiallelic selection in a finite population and show how it may be used to develop theoretical models of biological systems of balancing selection such as plant gametophytic self-incompatibility loci. We propose new expressions for the stationary distribution of allele frequencies under selection and use them to show that the continuous-time Markov chain describing allele frequency change with exchangeable selection and Moran-model reproduction is reversible. We then use the reversibility property to derive the expected allele frequency spectrum in a finite population for several general models of multiallelic selection. Using simulations, we show that our approach is valid over a broader range of parameters than previous analyses of balancing selection based on diffusion approximations to the Wright-Fisher model of reproduction. Our results can be applied to any model of multiallelic selection in which fitness is solely a function of allele frequency.
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Registered trials
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