ArticleDevelopment (Cambridge, England)2009
Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 64 citations in OpenAlex.
- Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors.Nature communications · 2026Article
- Development of ectodermal and endodermal taste buds.Developmental biology · 2025Review
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Single-cell transcriptomic atlas of taste papilla aging.Aging cell · 2024Article
- Reconstructing signaling history of single cells with imaging-based molecular recording.bioRxiv : the preprint server for biology · 2024Article
- Article
- The Reign of Follistatin in Tumors and Their Microenvironment: Implications for Drug Resistance.Biology · 2024Review
- Article
- Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme.Development (Cambridge, England) · 2023Article
- A shark-inspired general model of tooth morphogenesis unveils developmental asymmetries in phenotype transitions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The sense of taste: Development, regeneration, and dysfunction.WIREs mechanisms of disease · 2022Review
- Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea.Science advances · 2022Article
- Taste buds are not derived from neural crest in mouse, chicken, and zebrafish.Developmental biology · 2021Article
- Action of Actomyosin Contraction WithFrontiers in physiology · 2020Article
- Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues.Genesis (New York, N.Y. : 2000) · 2020Article
- Developmental plasticity of epithelial stem cells in tooth and taste bud renewal.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Early taste buds are from ShhBiochemical and biophysical research communications · 2019Article
- Article
- SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis.Development (Cambridge, England) · 2018Article
- Gli3 is a negative regulator of Tas1r3-expressing taste cells.PLoS genetics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The regenerative capacity of many placode-derived epithelial structures makes them of interest for understanding the molecular control of epithelial stem cells and their niches. Here, we investigate the interaction between the developing epithelium and its surrounding mesenchyme in one such system, the taste papillae and sensory taste buds of the mouse tongue. We identify follistatin (FST) as a mesenchymal factor that controls size, patterning and gustatory cell differentiation in developing taste papillae. FST limits expansion and differentiation of Sox2-expressing taste progenitor cells and negatively regulates the development of taste papillae in the lingual epithelium: in Fst(-/-) tongue, there is both ectopic development of Sox2-expressing taste progenitors and accelerated differentiation of gustatory cells. Loss of Fst leads to elevated activity and increased expression of epithelial Bmp7; the latter effect is consistent with BMP7 positive autoregulation, a phenomenon we demonstrate directly. We show that FST and BMP7 influence the activity and expression of other signaling systems that play important roles in the development of taste papillae and taste buds. In addition, using computational modeling, we show how aberrations in taste papillae patterning in Fst(-/-) mice could result from disruption of an FST-BMP7 regulatory circuit that normally suppresses noise in a process based on diffusion-driven instability. Because inactivation of Bmp7 rescues many of the defects observed in Fst(-/-) tongue, we conclude that interactions between mesenchyme-derived FST and epithelial BMP7 play a central role in the morphogenesis, innervation and maintenance of taste buds and their stem/progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.