ArticleJournal of the Royal Society, Interface2009
Spine-shaped gold protrusions improve the adherence and electrical coupling of neurons with the surface of micro-electronic devices.
Article in Journal of the Royal Society, Interface, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Bioinspired organic materials for seamless neurohybrid interfaces: from material design to living electronics.Materials horizons · 2026Review
- How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Just a little prick: careful cell contacts enabled by ceramic nanostraws.Pflugers Archiv : European journal of physiology · 2026Article
- Review
- Multi-material Electrohydrodynamic Printing of Bioelectronics with Sub-Microscale 3D Gold Pillars for In Vitro Extra- and Intra-Cellular Electrophysiological Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors.Microsystems & nanoengineering · 2024Review
- Streamlining the interface between electronics and neural systems for bidirectional electrochemical communication.Chemical science · 2023Review
- Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and Microelectrode Arrays.Micromachines · 2023Review
- Low Surface Potential with Glycoconjugates Determines Insect Cell Adhesion at Room Temperature.The journal of physical chemistry letters · 2022Article
- Shell microelectrode arrays (MEAs) for brain organoids.Science advances · 2022Article
- Enhanced magnetic transduction of neuronal activity by nanofabricated inductors quantified via finite element analysis.Journal of neural engineering · 2022Article
- Cellular nanointerface of vertical nanostructure arrays and its applications.Nanoscale advances · 2022Review
- Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane.Chemical reviews · 2022Article
- Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks.Advanced functional materials · 2022Article
- Use of an invertebrate animal model (Frontiers in neuroscience · 2022Review
- Synthesis of encapsulated ZnO nanowires provide low impedance alternatives for microelectrodes.PloS one · 2022Article
- Integrated Au-Nanoroded Biosensing and Regulating Platform for Photothermal Therapy of Bradyarrhythmia.Research (Washington, D.C.) · 2022Article
- Considerations and recent advances in nanoscale interfaces with neuronal and cardiac networks.Applied physics reviews · 2021Review
- Three dimensional microelectrodes enable high signal and spatial resolution for neural seizure recordings in brain slices and freely behaving animals.Scientific reports · 2021Article
- Recent advances in three-dimensional microelectrode array technologies for in vitro and in vivo cardiac and neuronal interfaces.Biosensors & bioelectronics · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interfacing neurons with micro- and nano-electronic devices has been a subject of intense study over the last decade. One of the major problems in assembling efficient neuro-electronic hybrid systems is the weak electrical coupling between the components. This is mainly attributed to the fundamental property of living cells to form and maintain an extracellular cleft between the plasma membrane and any substrate to which they adhere. This cleft shunts the current generated by propagating action potentials and thus reduces the signal-to-noise ratio. Reducing the cleft thickness, and thereby increasing the seal resistance formed between the neurons and the sensing surface, is thus a challenge and could improve the electrical coupling coefficient. Using electron microscopic analysis and field potential recordings, we examined here the use of gold micro-structures that mimic dendritic spines in their shape and dimensions to improve the adhesion and electrical coupling between neurons and micro-electronic devices. We found that neurons cultured on a gold-spine matrix, functionalized by a cysteine-terminated peptide with a number of RGD repeats, readily engulf the spines, forming tight apposition. The recorded field potentials of cultured Aplysia neurons are significantly larger using gold-spine electrodes in comparison with flat electrodes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.