ArticleProceedings. Biological sciences2009
Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice.
Article in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Developmental Trajectories of Anhedonia in Preclinical Models.Current topics in behavioral neurosciences · 2022Article
- Within-Family Environment and Cross-Fostering Stress Affect Behavior and Physiology in Wild Cavies (Frontiers in psychology · 2020Article
- Effect of early experience on neuronal and behavioral responses to con- and heterospecific odors in closely related Mus taxa: epigenetic contribution in formation of precopulatory isolation.BMC evolutionary biology · 2019Article
- Article
- Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?Behavioral and brain functions : BBF · 2015Review
- Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice.Journal of negative results in biomedicine · 2015Article
- Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression.Molecular psychiatry · 2015Article
- Epigenetic programming of reward function in offspring: a role for maternal diet.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Article
- DNA methylation as a mechanism of nutritional plasticity: limited support from horned beetles.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2013Article
- Empirical testing of hypotheses about the evolution of genomic imprinting in mammals.Frontiers in neuroanatomy · 2013Article
- Foster dams rear fighters: strain-specific effects of within-strain fostering on aggressive behavior in male mice.PloS one · 2013Article
- Genomic imprinting and genetic effects on muscle traits in mice.BMC genomics · 2012Article
- Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes.Epigenomics · 2012Review
- Genotype-dependent responses to levels of sibling competition over maternal resources in mice.Heredity · 2012Article
- Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood.The Journal of physiology · 2011Article
- Behavioral epigenetics.Annals of the New York Academy of Sciences · 2011Article
- Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees.Genetics, selection, evolution : GSE · 2011Article
- Development of fearfulness in birds: genetic factors modulate non-genetic maternal influences.PloS one · 2011Article
- Parent-of-origin effects on voluntary exercise levels and body composition in mice.Physiological genomics · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The interaction between maternally provided environment and offspring genotype is a major determinant of offspring development and fitness in many organisms. Recent research has demonstrated that not only genetic effects, but also epigenetic effects may be subject to modifications by the maternal environment. Genomic imprinting resulting in parent-of-origin-dependent gene expression is among the best studied of epigenetic effects. However, very little is known about the degree to which genomic imprinting effects can be modulated by the maternally provided environment, which has important implications for phenotypic plasticity. In this study, we investigated this unresolved question using a cross-fostering design in which mouse pups were nursed by either their own or an unrelated mother. We scanned the entire genome to search for quantitative trait loci whose effects depend on cross-fostering and detected 10 of such loci. Of the 10 loci, 4 showed imprinting by cross-foster interactions. In most cases, the interaction effect was due to the presence of an effect in either cross-fostered or non-cross-fostered animals. Our results demonstrate that genomic imprinting effects may often be modified by the maternal environment and that such interactions can impact key fitness-related traits suggesting a greater plasticity of genomic imprinting than previously assumed.
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