ArticleBMC medical genetics2009
Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis.European heart journal · 2014 · on this mapPooled it
- Interleukin 18 and coronary heart disease: prospective study and systematic review.Atherosclerosis · 2011Pooled it
- Transcriptome profiles of the skeletal muscle of mature cows during feed restriction and realimentation.BMC research notes · 2021Article
- Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis.BMC cardiovascular disorders · 2021Article
- Uncovering Potential lncRNAs and mRNAs in the Progression From Acute Myocardial Infarction to Myocardial Fibrosis to Heart Failure.Frontiers in cardiovascular medicine · 2021Article
- Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels.Circulation. Cardiovascular genetics · 2015Article
- Canonical correlation analysis for gene-based pleiotropy discovery.PLoS computational biology · 2014Article
- The role of interleukin-18 in the metabolic syndrome.Cardiovascular diabetology · 2010Review
- Implications of genetic polymorphisms in inflammation-induced atherosclerosis.The open cardiovascular medicine journal · 2010Article
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin-18 is a pro-inflammatory cytokine suspected to be associated with atherosclerosis and its complications. We had previously shown that one single nucleotide polymorphism (SNP) of the IL18 gene was associated with cardiovascular disease (CVD) through an interaction with smoking. As a further step for elucidating the contribution of the IL-18 pathway to the etiology of CVD, we here investigated the association between the genetic variability of two IL-18 receptor genes, IL18R1 and IL18RAP, with the risk of developing CVD.
methodsEleven tagging SNPs, 5 in IL18R1 and 6 in IL18RAP, characterizing the haplotypic variability of the corresponding genes; were genotyped in 5 European prospective CVD cohorts including 1416 cases and 1772 non-cases, as part of the MORGAM project. Both single-locus and haplotypes analyses were carried out to investigate the association of these SNPs with CVD.
resultsWe did not find any significant differences in allele, genotype and haplotype frequencies between cases and non-cases for either of the two genes. Moreover, the search for interactions between SNPs located in different genes, including 5 IL18 SNPs previously studied in the MORGAM project, and between SNPs and environmental factors remained unfruitful.
conclusionOur analysis suggests that the variability of IL18R1 and IL18RAP genes are unlikely to contribute to modulate the risk of CVD.
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