ArticleThe European journal of neuroscience2009
Corticosterone and dehydroepiandrosterone in songbird plasma and brain: effects of season and acute stress.
Article in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulfate (DHEA-S) in Broiler Plasma: Analytical Validation of Immunoassays and Comparative Overview Across Avian Species.Animals : an open access journal from MDPI · 2026Article
- Glucocorticoid production in the thymus and brain: Immunosteroids and neurosteroids.Brain, behavior, & immunity - health · 2021Article
- The stressed brain: regional and stress-related corticosterone and stress-regulated gene expression in the adult zebra finch (Taeniopygia guttata).Journal of neuroendocrinology · 2020Article
- Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters.Hormones and behavior · 2020Article
- Measurement of 11-dehydrocorticosterone in mice, rats and songbirds: Effects of age, sex and stress.General and comparative endocrinology · 2019Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals.Conservation physiology · 2018Article
- Neural Androgen Synthesis and Aggression: Insights From a Seasonally Breeding Rodent.Frontiers in endocrinology · 2018Review
- Determinants and significance of corticosterone regulation in the songbird brain.General and comparative endocrinology · 2016Review
- Steroids in the Avian Brain: Heterogeneity across Space and Time.Journal of ornithology · 2015Article
- Rapid Effects of Estradiol on Aggression in Birds and Mice: The Fast and the Furious.Integrative and comparative biology · 2015Review
- Region-specific neural corticosterone patterns differ from plasma in a male songbird.Endocrinology · 2014Article
- Article
- Acute stress differentially affects aromatase activity in specific brain nuclei of adult male and female quail.Endocrinology · 2011Article
- DHEA and estradiol levels in brain, gonads, adrenal glands, and plasma of developing male and female European starlings.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Measurement of steroid concentrations in brain tissue: methodological considerations.Frontiers in endocrinology · 2011Article
- Steroid concentrations in plasma, whole blood and brain: effects of saline perfusion to remove blood contamination from brain.PloS one · 2010Article
- Aggressive interactions rapidly increase androgen synthesis in the brain during the non-breeding season.Hormones and behavior · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prolonged increases in plasma glucocorticoids can exacerbate neurodegeneration. In rats, these neurodegenerative effects can be reduced by dehydroepiandrosterone (DHEA), an androgen precursor with anti-glucocorticoid actions. In song sparrows, season and acute restraint stress affect circulating levels of corticosterone and DHEA, and the effects of stress differ in plasma collected from the brachial and jugular veins. Jugular plasma is an indirect index of the neural steroidal milieu. Here, we directly measured corticosterone and DHEA in several brain regions and jugular plasma, and examined the effects of season and acute restraint stress (30 min) (n = 571 samples). Corticosterone levels were up to 10x lower in brain than in jugular plasma. In contrast, DHEA levels were up to 5x higher in brain than in jugular plasma and were highest in the hippocampus. Corticosterone and DHEA concentrations were strongly seasonally regulated in plasma but, surprisingly, not seasonally regulated in brain. Acute stress increased corticosterone levels in plasma and brain, except during the molt, when stress unexpectedly decreased corticosterone levels in the hippocampus. Acute stress increased DHEA levels in plasma during the molt but had no effects on DHEA levels in brain. This is the first study to measure (i) corticosterone or DHEA levels in the brain of adult songbirds and (ii) seasonal changes in corticosterone or DHEA levels in the brain of any species. These results highlight several critical differences between systemic and local steroid concentrations and the difficulty of using circulating steroid levels to infer local steroid levels within the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.