ReviewThe European journal of neuroscience2009
Physiological markers of local sleep.
Review in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- The sleep-deprived blood-brain barrier: Does the Brain's gatekeeper adapt or merely fail slowly?Neurobiology of sleep and circadian rhythms · 2026Review
- Activity driven sleep dynamics: A conceptual modeling study.PloS one · 2026Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- Neural fatigue by passive induction: repeated stimulus exposure results in cognitive fatigue and altered representations in task-relevant networks.Communications biology · 2023Article
- Predicting lapses of attention with sleep-like slow waves.Nature communications · 2021Article
- Astroglial Calcium Signaling Encodes Sleep Need in Drosophila.Current biology : CB · 2021Article
- Mind-wandering Is Accompanied by Both Local Sleep and Enhanced Processes of Spatial Attention Allocation.Cerebral cortex communications · 2021Article
- Sleep restriction and human physiology and behavior: questions posed, answers found?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Chronic BACE-1 Inhibitor Administration in TASTPM Mice (APP KM670/671NL and PSEN1 M146V Mutation): An EEG Study.International journal of molecular sciences · 2020Article
- Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity.eLife · 2020Article
- Local sleep.Sleep medicine reviews · 2019Review
- The neuron-specific interleukin-1 receptor accessory protein alters emergent network state propertiesNeurobiology of sleep and circadian rhythms · 2019Article
- Sleepiness as a Local Phenomenon.Frontiers in neuroscience · 2019Review
- Tumor necrosis factor alpha in sleep regulation.Sleep medicine reviews · 2018Review
- In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation.Scientific reports · 2018Article
- State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability.Frontiers in systems neuroscience · 2018Article
- Sleep function: Toward elucidating an enigma.Sleep medicine reviews · 2016Review
- The occurrence of individual slow waves in sleep is predicted by heart rate.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Substantial evidence suggests that brain regions that have been disproportionately used during waking will require a greater intensity and/or duration of subsequent sleep. For example, rats use their whiskers in the dark and their eyes during the light, and this is manifested as a greater magnitude of electroencephalogram (EEG) slow-wave activity in the somatosensory and visual cortex during sleep in the corresponding light and dark periods respectively. The parsimonious interpretation of such findings is that sleep is distributed across local brain regions and is use-dependent. The fundamental properties of sleep can also be experimentally defined locally at the level of small neural assemblies such as cortical columns. In this view, sleep is orchestrated, but not fundamentally driven, by central mechanisms. We explore two physiological markers of local, use-dependent sleep, namely, an electrical marker apparent as a change in the size and shape of an electrical evoked response, and a metabolic marker evident as an evoked change in blood volume and oxygenation delivered to activated tissue. Both markers, applied to cortical columns, provide a means to investigate physiological mechanisms for the distributed homeostatic regulation of sleep, and may yield new insights into the consequences of sleep loss and sleep pathologies on waking brain function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.