ArticleAmerican journal of hematology2009
Associations of factor VIIIc, D-dimer, and plasmin-antiplasmin with incident cardiovascular disease and all-cause mortality.
Article in American journal of hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.PloS one · 2013Pooled it
- Dietary Supplementation with Selenium and Coenzyme QNutrients · 2021Trial
- Inflammation-Related Morbidity and Mortality Among HIV-Positive Adults: How Extensive Is It?Journal of acquired immune deficiency syndromes (1999) · 2018Trial
- Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging.Frontiers in immunology · 2018Trial
- Association of D-dimer levels with all-cause mortality in a healthy adult population: findings from the MOLI-SANI study.Haematologica · 2013Trial
- Short- and long-term risk stratification in acutely ill medical patients by implementing D-dimer in the emergency setting - A prospective cohort study.American heart journal plus : cardiology research and practice · 2026Article
- The Association of Elevated Factor VIII and von Willebrand Factor (vWF) Levels with SYNTAX Score in Patients with Chronic Coronary Syndrome.Biomedicines · 2025Article
- Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer's disease and AD-related dementia or cognitive decline: a prospective cohort study.Frontiers in aging neuroscience · 2024Article
- A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies.International journal of molecular sciences · 2023Article
- Association between fatty liver index and blood coagulation markers: a population-based study.Lipids in health and disease · 2023Article
- Fibrin degradation products and survival in patients with chronic obstructive pulmonary disease: a protocolized prospective observational study.Respiratory research · 2023Observational
- Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study.Medicina (Kaunas, Lithuania) · 2023Article
- Associations of Hemostatic Variables with Cardiovascular Disease and Total Mortality: The Glasgow MONICA Study.TH open : companion journal to thrombosis and haemostasis · 2022Article
- Associations of D-Dimer with Computed Tomographic Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study.Annals of the American Thoracic Society · 2021Article
- Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis.Journal of thrombosis and haemostasis : JTH · 2021Article
- The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis.Scientific reports · 2021Article
- D-Dimer: A Potential Solution to Problems of Cancer Screening, Surveillance, and Prognosis Assessment.Cureus · 2021Review
- Thrombotic biomarkers for risk prediction of malignant disease recurrence in patients with early stage breast cancer.Haematologica · 2020Article
- Coagulation factor VIII: Relationship to cardiovascular disease risk and whole genome sequence and epigenome-wide analysis in African Americans.Journal of thrombosis and haemostasis : JTH · 2020Article
- Resting heart rate and incident venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis.Open heart · 2020Observational
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
To examine the associations of three understudied hemostatic factors--D-dimer, factor VIII(c), and plasmin-antiplasmin (PAP) complex--with incident cardiovascular disease (CVD) and all cause mortality in the Multiethnic Study of Atherosclerosis cohort. Hemostatic factors were measured at baseline in 45-84-year-old patients (n = 6,391) who were free of clinically recognized CVD. Over 4.6 years of follow-up, we identified 307 CVD events, 207 hard coronary heart disease events, and 210 deaths. D-dimer, factor VIII(c), and PAP were not associated with CVD incidence after adjustment for other risk factors. In contrast, each factor was associated positively with total mortality, and D-dimer and factor VIII(c) were associated positively with cancer mortality. When modeled as ordinal variables and adjusted for risk factors, total mortality was greater by 33% (95% CI 15-54) for each quartile increment of D-dimer, 26% (11-44) for factor VIIIc, and 20% (4-38) for PAP. This prospective cohort study did not find D-dimer, factor VIII(c), or PAP to be risk factors for CVD. Instead, elevated levels of these three hemostatic factors were associated independently with increased risk of death. Elevated D-dimer and factor VIII(c) were associated with increased cancer death.
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Registered trials
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