ArticleDevelopmental neurobiology2009
A critical step for postsynaptic F-actin organization: regulation of Baz/Par-3 localization by aPKC and PTEN.
Article in Developmental neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Dynein-driven regulation of postsynaptic membrane architecture and synaptic function.Journal of cell science · 2025Article
- Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila.PLoS biology · 2025Article
- Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila: no evidence for localization to the nucleus and the neuromuscular junction.Biology open · 2024Article
- Immunohistochemical Analysis of the Drosophila Larval Neuromuscular Junction.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila.Communications biology · 2023Article
- The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Article
- Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex ineLife · 2018Article
- Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours inBioMed research international · 2017Article
- Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila embryo.Molecular biology of the cell · 2016Article
- Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex.PloS one · 2016Article
- Polarity Determinants in Dendritic Spine Development and Plasticity.Neural plasticity · 2016Review
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function.Molecular biology of the cell · 2015Article
- Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.Molecular and cellular neurosciences · 2014Article
- miR-8 controls synapse structure by repression of the actin regulator enabled.Development (Cambridge, England) · 2014Article
- Terminal axonal arborization and synaptic bouton formation critically rely on abp1 and the arp2/3 complex.PloS one · 2014Article
- The cell polarity scaffold Lethal Giant Larvae regulates synapse morphology and function.Journal of cell science · 2013Article
- Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope.Cell reports · 2013Article
- Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.Genes & development · 2012Article
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4 authors at 1 institution in 1 country.
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Abstract
Actin remodeling has emerged as a critical process during synapse development and plasticity. Thus, understanding the regulatory mechanisms controlling actin organization at synapses is exceedingly important. Here, we used the highly plastic Drosophila neuromuscular junction (NMJ) to understand mechanisms of actin remodeling at postsynaptic sites. Previous studies have suggested that the actin-binding proteins Spectrin and Coracle play a critical role in NMJ development and the anchoring of glutamate receptors most likely through actin regulation. Here, we show that an additional determinant of actin organization at the postsynaptic region is the PDZ protein Baz/Par-3. Decreasing Baz levels in postsynaptic muscles has dramatic consequences for the size of F-actin and spectrin domains at the postsynaptic region. In turn, proper localization of Baz at this site depends on both phosphorylation and dephosphorylation events. Baz phosphorylation by its binding partner, atypical protein kinase C (aPKC), is required for normal Baz targeting to the postsynaptic region. However, the retention of Baz at this site depends on its dephosphorylation mediated by the lipid and protein phosphatase PTEN. Misregulation of the phosphorylation state of Baz by genetic alterations in PTEN or aPKC activity has detrimental consequences for postsynaptic F-actin and spectrin localization, synaptic growth, and receptor localization. Our results provide a novel mechanism of postsynaptic actin regulation through Baz, governed by the antagonistic actions of aPKC and PTEN. Given the conservation of these proteins from worms to mammals, these results are likely to provide new insight into actin organization pathways. (c) 2009 Wiley Periodicals, Inc. Develop Neurobiol 2009.
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