ReviewVirchows Archiv : an international journal of pathology2009
Cancer invasion and metastasis: interacting ecosystems.
Review in Virchows Archiv : an international journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment.Frontiers in oncology · 2022Pooled it
- Article
- Molecular mechanism of bone metastasis in breast cancer.Frontiers in oncology · 2024Review
- Transforming Cancer Treatment with Nanotechnology: The Role of Berberine as a Star Natural Compound.International journal of nanomedicine · 2024Review
- Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway.Journal of cancer research and clinical oncology · 2023Article
- Identification ofCell journal · 2021Article
- Giulio Gabbiani and the discovery of myofibroblasts.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Differential expression of E-cadherin and P-cadherin in pT3 prostate cancer: correlation with clinical and pathological features.Virchows Archiv : an international journal of pathology · 2018Article
- Effects of radiation on the metastatic process.Molecular medicine (Cambridge, Mass.) · 2018Review
- The role of vitamin D in hepatic metastases from colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Review
- Phase II study on early start of chemotherapy after excising primary colorectal cancer with distant metastases (Pearl Star 02).Annals of gastroenterological surgery · 2017Article
- Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter.Biochemistry and biophysics reports · 2017Article
- Celastrol negatively regulates cell invasion and migration ability of human osteosarcoma via downregulation of the PI3K/Akt/NF-κB signaling pathwayOncology letters · 2016Article
- γ-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.Cell and tissue research · 2016Article
- Aberrant expression of osteopontin and E-cadherin indicates radiation resistance and poor prognosis for patients with cervical carcinoma.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- RNAi-mediated silencing of AQP1 expression inhibited the proliferation, invasion and tumorigenesis of osteosarcoma cells.Cancer biology & therapy · 2015Article
- The Association of Serum IL-33 and sST2 with Breast Cancer.Disease markers · 2015Article
- A mechanically-induced colon cancer cell population shows increased metastatic potential.Molecular cancer · 2014Article
- Stimuli-induced organ-specific injury enhancement of organotropic metastasis in a spatiotemporal regulation.Pathology oncology research : POR · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant tumors invade and metastasize. They consist of cancer cells, evolving through genetic and epigenetic modulation, mixed with tumor-associated host cells, emerging from resident or bone marrow-derived precursors. These cells establish ecosystems to activate cellular programs for local invasion and distant metastasis. Characteristic of such malignancy-related activities is communication inside ecosystems between cells, ligands, receptor protein complexes, and signaling pathways as well as between ecosystems comprising the primary tumor, lymph node and distant metastasis, bone marrow and blood and lymph circulation. Complexity is another characteristic, resulting from: heterogeneity of the cell populations; the numbers of promoter and suppressor genes, their levels of regulation, and the pleiotropic activities of their products; biological redundancy of the molecular mechanisms underpinning invasion-related activities. Clinical attention is paid to putative new targets, namely host cells, individual molecules and their signaling pathways, as well as the effects of current treatment on invasion and metastasis.
Indexed as
Identifiers
19471961What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.