Evidence map›Paper›PMID 19471934›Full record

ReviewRheumatology international2009

Cogan's syndrome: present and future directions.

Grainne Murphy, Miriam O Sullivan, Fergus Shanahan, Sinead Harney, Michael Molloy

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Optimal management of Cogan's syndrome: a multidisciplinary approach.Journal of multidisciplinary healthcare · 2018
    Review
  6. Cogan's syndrome--clinical guidelines and novel therapeutic approaches.Clinical reviews in allergy & immunology · 2014
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Grainne MurphyDepartment of Rheumatology, Cork University Hospital, Wilton, Cork, Ireland. grainne927@yahoo.com
Miriam O Sullivan
Fergus Shanahan
Sinead Harney
Michael Molloy
Cork University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cogan's syndrome, typified by the combination of interstitial keratitis and immune-mediated sensorineural hearing loss, is a rare condition, and commonly associated with a diagnostic delay. Using a standard search protocol, we review the literature to date, focusing on a number of key areas pertaining to diagnosis, presentation and treatment. Using a case illustration of atypical disease which led to fulminant aortic regurgitation, we highlight the need for continued and collaborative research in order to identify negative prognostic factors and thus tailor therapeutic regimens. Atypical Cogan's syndrome is more commonly associated with systemic manifestations than typical disease, and may be refractory to immunosuppressive treatment. We discuss the application of laboratory (e.g antibodies targeting inner ear antigens) and radiological (PET-CT) aids to disease confirmation and detection of sub-clinical vascular inflammation. As illustrated by the included case description, some patients remain refractory to intense immunosuppression and delineation of adverse prognostic factors which may direct treatment, perhaps including the use of PET-CT, will contribute in the future to improving patient outcomes.

Indexed as

Adrenal Cortex HormonesAdultAzathioprineDose-Response Relationship, DrugFatal OutcomeFemaleHearing Loss, SensorineuralHumansKeratitisPractice Guidelines as TopicPrognosisRandomized Controlled Trials as TopicSyndromeUveitisVascular DiseasesAdrenal Cortex HormonesAzathioprine

Identifiers

PMID19471934
OpenAlexW2018692010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.