ArticleJournal of gynecologic oncology2009
Association between bacterial vaginosis and cervical intraepithelial neoplasia.
Article in Journal of gynecologic oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.PloS one · 2012Pooled it
- Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis.BMC infectious diseases · 2011Pooled it
- Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection.BMC infectious diseases · 2018Trial
- Evaluation of microbial enzymes in normal and abnormal cervicovaginal fluids of cervical dysplasia: a case control study.BioMed research international · 2014Trial
- The cervicovaginal microbiome: an emerging determinant of HPV infection and disease.Journal of virology · 2026Review
- Article
- Bacterial Vaginosis Decreases the Risk of Cervical Cytological Abnormalities.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Common Microbial Genital Infections and Their Impact on the Innate Immune Response to HPV in Cervical Cells.Pathogens (Basel, Switzerland) · 2022Article
- Aerobic Vaginitis-Underestimated Risk Factor for Cervical Intraepithelial Neoplasia.Diagnostics (Basel, Switzerland) · 2021Article
- The vaginal metabolome and microbiota of cervical HPV-positive and HPV-negative women: a cross-sectional analysis.BJOG : an international journal of obstetrics and gynaecology · 2020Article
- Revealing the Disturbed Vaginal Micobiota Caused by Cervical Cancer Using High-Throughput Sequencing Technology.Frontiers in cellular and infection microbiology · 2020Article
- Article
- Inhibitory Effect of Vaginal Lactobacillus Supernatants on Cervical Cancer Cells.Probiotics and antimicrobial proteins · 2018Article
- Bacterial Vaginosis and Cervical Intraepithelial Neoplasia: Is there an Association or is Co-Existence Incidental?Asian Pacific journal of cancer prevention : APJCP · 2017Article
- High Prevalence ofBioMed research international · 2017Article
- The Effect of Lactobacillus crispatus and Lactobacillus rhamnosusCulture Supernatants on Expression of Autophagy Genes and HPV E6 and E7 Oncogenes in The HeLa Cell Line.Cell journal · 2016Article
- Association between Obesity and Cervical Microflora Dominated by Lactobacillus iners in Korean Women.Journal of clinical microbiology · 2015Article
- High incidence of oncogenic HPV genotypes found in women from Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study.BMC infectious diseases · 2013Article
- The Strong Protective Effect of Circumcision against Cancer of the Penis.Advances in urology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection.
methodsA total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups.
resultsThere was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity.
conclusionThere was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.