ArticleJournal of gynecologic oncology2008
Does pretreatment HPV viral load correlate with prognosis in patients with early stage cervical carcinoma?
Article in Journal of gynecologic oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- HPV viral load predicts immune exhaustion and prognosis in cervical neoplasia.Frontiers in immunology · 2026Article
- Multi-Target Molecular Detection of Sexually Transmitted Infections in Women Living with HIV in Northeastern Brazil.Tropical medicine and infectious disease · 2025Article
- Clinical analysis of 312 patients with stage IB1-IIA2 cervical squamous cell carcinoma and research on the influencing factors of postoperative recurrence.BMC women's health · 2023Article
- HPV Types Distribution in General Female Population and in Women Diagnosed with Cervical Cancer Across Western KazakhstanAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Human Papillomavirus Status in Primary Lesions and Pelvic Lymph Nodes and Its Prognostic Value in Cervical Cancer Patients with Lymph Node Metastases.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- High risk human papillomavirus prevalence and genotype distribution among women infected with HIV in Manaus, Amazonas.Virology journal · 2018Article
- Augmented Activity of Cyclooxygenase-2 in Tissue and Serum of Patients With Cervical Cancer.Journal of clinical laboratory analysis · 2016Article
- Human papillomavirus (HPV) genome status & cervical cancer outcome--A retrospective study.The Indian journal of medical research · 2015Article
- Low initial human papillomavirus viral load may indicate worse prognosis in patients with cervical carcinoma treated with surgery.Journal of gynecologic oncology · 2015Article
- Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia.Journal of cancer prevention · 2013Review
- Article
- Association between bacterial vaginosis and cervical intraepithelial neoplasia.Journal of gynecologic oncology · 2009Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent data suggest that pretreatment HPV (Human papillomavirus) viral load is useful to predict the severity of intraepithelial lesions of the uterine cervix and formulate a treatment plan. However, the relationship between initial HPV viral load and prognosis of cervical cancer patients has not yet been clearly defined. The objective of this study was to determine whether HPV viral load has prognostic significance in patients with early stage cervical carcinoma treated by surgery.
methodsA retrospective review of all patients with early stage cervical carcinoma who underwent radical hysterectomy and pelvic lymphadenectomy at our institution from August 2003 to December 2007 was conducted. Patients were included only if they had pretreatment Hybrid Capture II test for HPV DNA detection.
resultsWe identified 34 patients who met the inclusion criteria. Two groups were identified: patients who had low HPV viral load (</=100 RLU) versus those who had high viral load (>100 RLU). There were no differences in age, FIGO stage, histology, pathologic risk factors - tumor size, deep stromal invasion, lymph-vascular space invasion, parametrial extensions, vaginal margin involvement, and lymph node metastasis - and adjuvant CCRT. There was no significant difference of disease-free survival regard to pretreatment HPV viral load (p=0.7756).
conclusionIn our study, survival was not significantly different between early stage cervical cancer patients who had low and high pretreatment HPV viral load. It seems that pretreatment HPV viral load may not be of help to predict disease prognosis.
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