ArticleEuropean journal of human genetics : EJHG2009
Preimplantation genetic diagnosis for mitochondrial DNA disorders: ethical guidance for clinical practice.
Article in European journal of human genetics : EJHG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children.Biochemical Society transactions · 2016Article
- A national perspective on prenatal testing for mitochondrial disease.European journal of human genetics : EJHG · 2014Article
- Mitochondrial dynamics and inheritance during cell division, development and disease.Nature reviews. Molecular cell biology · 2014Review
- Preimplantation genetic diagnosis for inherited neurological disorders.Nature reviews. Neurology · 2014Review
- Ethics in prion disease.Progress in neurobiology · 2013Article
- Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.Cold Spring Harbor perspectives in biology · 2013Review
- Genomics and perinatal care.The New England journal of medicine · 2012Review
- Mitochondrial genetic diseases.Current opinion in pediatrics · 2010Review
- Singling out genetic disorders and disease.Genome medicine · 2010Article
- Transmission of mitochondrial DNA diseases and ways to prevent them.PLoS genetics · 2010Review
- Mitochondrial energetics and therapeutics.Annual review of pathology · 2010Review
- Mitochondrial Donation: A Boon or Curse for the Treatment of Incurable Mitochondrial Diseases.Journal of human reproductive sciencesReview
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Although morally acceptable in theory, preimplantation genetic diagnosis (PGD) for mitochondrial DNA (mtDNA) disorders raises several ethical questions in clinical practice. This paper discusses the major conditions for good clinical practice. Our starting point is that PGD for mtDNA mutations should as far as possible be embedded in a scientific research protocol. For every clinical application of PGD for mtDNA disorders, it is not only important to avoid a 'high risk of serious harm' to the future child, but also to consider to what extent it would be possible, desirable and proportional to try to reduce the health risks and minimize harm. The first issue we discuss is oocyte sampling, which may point out whether PGD is feasible for a specific couple. The second issue is whether one blastomere represents the genetic composition of the embryo as a whole -- and how this could (or should) be investigated. The third issue regards the cutoff points below which embryos are considered to be eligible for transfer. We scrutinize how to determine these cutoff points and how to use these cutoff points in clinical practice -- for example, when parents ask to take more or less risks. The fourth issue regards the number of cycles that can (or should) justifiably be carried out to find the best possible embryo. Fifth, we discuss whether follow-up studies should be conducted, particularly the genetic testing of children born after IVF/PGD. Finally, we offer the main information that is required to obtain a truly informed consent.
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