ArticleScience signaling2009
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Article in Science signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Adhesion G protein-coupled receptors.Pharmacological reviews · 2026Review
- Zebrafish and bioactive compounds: a bibliometric review.In silico pharmacology · 2025Article
- High incidence of imperforate vagina in ADGRA3-deficient mice.BMC biology · 2024Article
- The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer.Biochemical Society transactions · 2023Review
- Overexpression of Bruton Tyrosine Kinase Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer Cells.Analytical cellular pathology (Amsterdam) · 2023Article
- Cell-Based Double-Screening Method to Identify a Reliable Candidate for Osteogenesis-Targeting Compounds.Biomedicines · 2022Article
- Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.Neoplasia (New York, N.Y.) · 2021Article
- MicroRNA-885-5p promotes osteosarcoma proliferation and migration by downregulation of cell division cycle protein 73 homolog expression.Oncology letters · 2019Article
- NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/β-catenin signaling pathway and predicts good prognosis.Cancer biomarkers : section A of Disease markers · 2019Article
- Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Article
- PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.Nature communications · 2016Article
- Review
- Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?Oncotarget · 2015Review
- Targeting Wnt pathway in mantle cell lymphoma-initiating cells.Journal of hematology & oncology · 2015Article
- Bruton tyrosine kinase is a therapeutic target in stem-like cells from multiple myeloma.Cancer research · 2015Article
- Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.The Journal of biological chemistry · 2014Article
- Loss of connectivity in cancer co-expression networks.PloS one · 2014Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through beta-catenin is required in adults, because either elevation or attenuation of beta-catenin function has been linked to diverse diseases. To contribute to the identification of both protein and pharmacological regulators of this pathway, we describe a combinatorial screen that merged data from a high-throughput screen of known bioactive compounds with an independent focused small interfering RNA screen. Each screen independently revealed Bruton's tyrosine kinase (BTK) as an inhibitor of Wnt-beta-catenin signaling. Loss of BTK function in human colorectal cancer cells, human B cells, zebrafish embryos, and cells derived from X-linked agammaglobulinemia patients with a mutant BTK gene resulted in elevated Wnt-beta-catenin signaling, confirming that BTK acts as a negative regulator of this pathway. From affinity purification-mass spectrometry and biochemical binding studies, we found that BTK directly interacts with a nuclear component of Wnt-beta-catenin signaling, CDC73. Further, we show that BTK increased the abundance of CDC73 in the absence of stimulation and that CDC73 acted as a repressor of beta-catenin-mediated transcription in human colorectal cancer cells and B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.