Trial reportHypertension (Dallas, Tex. : 1979)2009
Age-related differences in the sympathetic-hemodynamic balance in men.
Trial report in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Effects of L-carnitine supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials.Journal of human hypertension · 2019Pooled it
- Does l-citrulline supplementation improve exercise blood flow in older adults?Experimental physiology · 2017Trial
- Altered neurovascular control of the resting circulation in human metabolic syndrome.The Journal of physiology · 2012Trial
- Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Beyond pooled analysis: sex-specific cardiovascular adverse event reporting signals with antiarrhythmic drugs in FAERS.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche.Bone research · 2026Review
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- Comparative assessment of hemodynamic changes and outcomes in ventilator weaning.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Dietary L-carnitine modulates oxidative stress, lipid metabolism, and pulmonary hypertension in chickens raised at high-altitude under cold stress.BMC veterinary research · 2025Article
- Differential effects of female aging on sympathetic blood pressure regulation at rest and during stress in humans.Physiological reports · 2025Article
- Sympathetic motor neuron dysfunction is a missing link in age-associated sympathetic overactivity.eLife · 2024Article
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
- Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity.bioRxiv : the preprint server for biology · 2024Article
- Aging and sympathetic transduction to blood pressure in humans: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2024Article
- Role of the autonomic nervous system in young, middle-aged, and older individuals with essential hypertension and sleep-related changes in neurocardiac regulation.Scientific reports · 2023Article
- Slowing down as we age: aging of the cardiac pacemaker's neural control.GeroScience · 2022Review
- Sympathetic-transduction in untreated hypertension.Journal of human hypertension · 2022Article
- Contribution of Peripheral Chemoreceptors to Exercise Intolerance in Heart Failure.Frontiers in physiology · 2022Review
- Brainstem network connectivity with mid-anterior insula predicts lower systolic blood pressure at rest in older adults with hypertension.Journal of human hypertension · 2021Article
- Forearm vascular resistance responses to the Valsalva maneuver in healthy young and older adults.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
As humans age, the tonic level of activity in sympathetic vasoconstrictor nerves increases and may contribute to age-related increases in blood pressure. In previous studies in normotensive young men with varying levels of resting sympathetic nerve activity, we observed a balance among factors contributing to blood pressure regulation, such that higher sympathetic activity was associated with lower cardiac output and lesser vascular responsiveness to alpha-adrenergic agonists, which limited the impact of high sympathetic activity on blood pressure. In the present study, we tested the hypothesis that older normotensive men would exhibit a similar balance among these variables (sympathetic nerve activity, cardiac output, and alpha-adrenergic responsiveness) but that this balance would be shifted toward higher sympathetic nerve activity values. We measured muscle sympathetic nerve activity, cardiac output, arterial pressure, and forearm vasoconstrictor responses in 17 older men and compared these with previous data collected in 14 younger men. Muscle sympathetic activity (burst incidence) was positively related to diastolic blood pressure in the older men (r=0.49; P=0.05); this relationship was not observed in young men. In addition, there was no relationship between cardiac output and muscle sympathetic activity (r=0.29; P>0.05) or between muscle sympathetic activity and vasoconstrictor responses in the older men (eg, norepinephrine: r=-0.21; P>0.05). Although our older subjects were normotensive, the relationship between muscle sympathetic nerve activity and diastolic blood pressure and the lack of "balance" among the other variables suggest that these changes with aging may contribute to the risk of sympathetically mediated hypertension in older humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.