ArticleCancer prevention research (Philadelphia, Pa.)2009
Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E).
Article in Cancer prevention research (Philadelphia, Pa.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Trial
- Phase IB randomized, double-blinded, placebo-controlled, dose escalation study of polyphenon E in women with hormone receptor-negative breast cancer.Cancer prevention research (Philadelphia, Pa.) · 2012Trial
- Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions.Cancer prevention research (Philadelphia, Pa.) · 2009Trial
- The interplay of exercise and green tea: a new road in cancer therapy.Cancer cell international · 2025Review
- Anticancer Therapeutic Effects of Green Tea Catechins (GTCs) When Integrated with Antioxidant Natural Components.Molecules (Basel, Switzerland) · 2023Review
- Processing Technologies for the Extraction of Value-Added Bioactive Compounds from Tea.Food engineering reviews · 2023Review
- Green Tea Catechins: Nature's Way of Preventing and Treating Cancer.International journal of molecular sciences · 2022Review
- Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.Molecules (Basel, Switzerland) · 2020Review
- Beneficial Properties of Green Tea Catechins.International journal of molecular sciences · 2020Review
- Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.Applied in vitro toxicology · 2019Article
- Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice.Carcinogenesis · 2013Article
- Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.Molecular carcinogenesis · 2011Article
- Green tea and prevention of esophageal and lung cancers.Molecular nutrition & food research · 2011Review
- Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Malignant Human Prostate Tumors.Translational oncology · 2011Article
- Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis.Molecular carcinogenesis · 2011Article
- Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.Pharmaceutical research · 2010Article
- Article
- Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail.Cancer prevention research (Philadelphia, Pa.) · 2009Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Green tea has been shown to exhibit cancer-preventive activities in preclinical studies. However, (-)-epigallocatechin-3-gallate (EGCG) alone was shown to be ineffective in preventing lung tumorigenesis in mice by aerosol administration. In this study, Polyphenon E and Polyphenon E without EGCG were administered by aerosol delivery to A/J mice 2 weeks after carcinogen treatment and continuing daily throughout the remainder of the study (20 weeks). An improved aerosol delivery system with a custom-built atomizer, an efficient solvent remove system, and a nose-only exposure chamber was used to provide aerosols with stable size distribution. There were no significant differences in the size distributions of Polyphenon E and Polyphenon E without EGCG. With a relatively low dose level (4.19 mg/kg), Polyphenon E decreased tumor multiplicity by 53%, whereas Polyphenon E without EGCG at the same dose failed to inhibit lung carcinogenesis. These results indicate that aerosol administration can be an effective approach in chemoprevention study, and aerosolized Polyphenon E can significantly inhibit pulmonary adenoma formation and growth in A/J mice. Furthermore, in aerosolized form, EGCG, which is thought to be the most active component of Polyphenon E, has to be present with other tea catechins to show chemopreventive activity on lung tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.