ArticleThe Journal of physiology2009
Time to fatigue is increased in mouse muscle at 37 degrees C; the role of iron and reactive oxygen species.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise.Antioxidants (Basel, Switzerland) · 2023Review
- Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle.Journal of muscle research and cell motility · 2015Article
- Uremic myopathy: is oxidative stress implicated in muscle dysfunction in uremia?Frontiers in physiology · 2015Review
- Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species.Frontiers in physiology · 2015Review
- The excitation-contraction coupling mechanism in skeletal muscle.Biophysical reviews · 2014Review
- Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle.The Journal of physiology · 2011Review
- Interactive processes link the multiple symptoms of fatigue in sport competition.Sports medicine (Auckland, N.Z.) · 2011Review
- Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue.American journal of physiology. Cell physiology · 2010Article
- Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres.European journal of applied physiology · 2010Review
- High temperature does not alter fatigability in intact mouse skeletal muscle fibres.The Journal of physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies exploring the rate of fatigue in isolated muscle at 37 degrees C have produced mixed results. In the present study, muscle fibre bundles from the mouse foot were used to study the effect of temperature on the rate of muscle fatigue. Provided iron was excluded from the solutions, time to fatigue at 37 degrees C was increased compared to 22 degrees C (125 +/- 8% of 22 degrees C fatigue time). In contrast, when iron was present (approximately 1 microM), fatigue was accelerated (68 +/- 10%). Iron can increase reactive oxygen species (ROS), which are believed to accelerate fatigue. The addition of 25-100 microM H(2)O(2) at 22 degrees C reduced time to fatigue to 80-20% of the control, respectively. Iron was added to cultured primary skeletal muscle cells to determine if iron could increase ROS production. Neither iron entry nor ROS production were detected in non-contracting muscle cells. The addition of 8-hydroxyquinoline, which facilitates iron entry, to iron-ascorbic acid solutions caused a rapid rise in intracellular iron and ROS. Our results indicate that time to fatigue in vitro is increased at 37 degrees C relative to 22 degrees C, but the addition of ROS can accelerate fatigue. An increase in muscle iron can accelerate ROS production, which may be important during or following exercise and in haemochromatosis, disuse atrophy and sarcopenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.