ArticleMolecular and cellular biology2009
Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Neuronal Agrin Promotes Proliferation of Primary Human Myoblasts in an Age-Dependent Manner.International journal of molecular sciences · 2022Article
- Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress.Journal of ginseng research · 2022Article
- Regulatory mechanisms of cytoneme-based morphogen transport.Cellular and molecular life sciences : CMLS · 2022Review
- Understanding of sarcopenia: from definition to therapeutic strategies.Archives of pharmacal research · 2021Review
- BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function.International journal of environmental research and public health · 2021Article
- c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation.Frontiers in cell and developmental biology · 2021Article
- Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism.Frontiers in nutrition · 2021Article
- Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy.Journal of cachexia, sarcopenia and muscle · 2018Article
- Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation.Skeletal muscle · 2018Article
- Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth.Journal of ginseng research · 2018Article
- Ginsenoside Rg1 fromJournal of ginseng research · 2017Article
- c-Abl regulates gastrointestinal muscularis propria homeostasis via ERKs.Scientific reports · 2017Article
- Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.PloS one · 2017Article
- PKN2 and Cdo interact to activate AKT and promote myoblast differentiation.Cell death & disease · 2016Article
- Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation.Molecular medicine reports · 2016Article
- Article
- miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling.International journal of molecular medicine · 2015Article
- Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenic differentiation.Skeletal muscle · 2015Article
- TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.The Journal of biological chemistry · 2012Article
- Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1.Molecular biology of the cell · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The p38 mitogen-activated protein kinase (MAPK) pathway is required for differentiation of skeletal myoblasts, but how the pathway is activated during this process is not well understood. One mechanism involves the cell surface receptor Cdo (also known as Cdon), which binds to Bnip-2 and JLP, scaffold proteins for Cdc42 and p38, respectively; formation of these complexes results in Bnip-2/Cdc42-dependent activation of p38. It has been reported that the tyrosine kinase Abl promotes myogenic differentiation in a manner dependent on its cytoplasmic localization, but the cytoplasmic signaling proteins with which it interacts to achieve this effect are unidentified. We report that Abl associates with both Cdo and JLP during myoblast differentiation. Abl binds a proline-rich motif in Cdo via its SH3 domain, and these regions of Abl and Cdo are required for their promyogenic effects. Cdo is important for full Abl kinase activity, and Abl is necessary for full activation of p38 MAPK, during myogenic differentiation. As seen with myoblasts depleted of Cdo, the diminished differentiation displayed by Abl-depleted cells is rescued by the expression of an activated form of the immediate upstream p38-activating kinase MAPK kinase 6. Abl's promyogenic effect is therefore linked to a multiprotein cell surface complex that regulates differentiation-dependent p38 activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.