ArticleJournal of the American Society of Nephrology : JASN2009
Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- CaActa physiologica (Oxford, England) · 2026Review
- Inactivation of epithelial sodium ion channel molecules serves as effective diagnostic biomarkers in clear cell renal cell carcinoma.Genes & genomics · 2023Article
- Structure and Function of the Bestrophin family of calcium-activated chloride channels.Channels (Austin, Tex.) · 2021Review
- Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular CaInternational journal of molecular sciences · 2021Article
- Review
- Oxalate induces type II epithelial to mesenchymal transition (EMT) in inner medullary collecting duct cells (IMCD)Oncotarget · 2019Article
- Genetic variations in Bestrophin‑1 and associated clinical findings in two Chinese patients with juvenile‑onset and adult‑onset best vitelliform macular dystrophy.Molecular medicine reports · 2018Article
- TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Review
- Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.Journal of Cancer · 2015Review
- Role of anoctamins in cancer and apoptosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Effects of Chinese Medicine Tong xinluo on Diabetic Nephropathy via Inhibiting TGF- β 1-Induced Epithelial-to-Mesenchymal Transition.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- A novel model of surgical injury in adult rat kidney: a "pouch model".Scientific reports · 2013Article
- Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia.American journal of physiology. Renal physiology · 2012Article
- Characterization of a novel splice variant of δ ENaC subunit in human lungs.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Cell cycle-dependent subcellular distribution of ClC-3 in HeLa cells.Histochemistry and cell biology · 2012Article
- Functional correlates of positional and gender-specific renal asymmetry in Drosophila.PloS one · 2012Article
- Expression and function of epithelial anoctamins.The Journal of biological chemistry · 2010Article
- ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.Pflugers Archiv : European journal of physiology · 2010Article
- Chloride channels: often enigmatic, rarely predictable.Annual review of physiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bestrophin 1 (Best1) controls intracellular Ca(2+) concentration, induces Ca(2+)-activated Cl(-) conductance, and increases proliferation of colon carcinoma cells. Here, we show that expression of Best1 in mouse renal collecting duct (CD) cells causes i) an increase in cell proliferation, ii) a loss of amiloride-sensitive Na(+) absorption, iii) induction of Ca(2+)-dependent Cl(-) conductance (CaCC), and iv) epithelial-to-mesenchymal transition. During conditions of high proliferation or when we exposed CD cells to serum or TGF-beta1, we observed upregulation of Best1, increased CaCC, redistribution of the epithelial-to-mesenchymal transition marker beta-catenin, and upregulation of vimentin. In contrast, suppression of Best1 by RNAi inhibited proliferation, reduced CaCC, and downregulated markers of EMT. CaCC and expression of Best1 were independent of the cell cycle but clearly correlated to cell proliferation and cell density. During renal inflammation in LPS-treated mice or after unilateral ureteral obstruction, we observed transient upregulation of Best1. These data indicate that repression of cell proliferation, CaCC, and expression of Best1 occurs during mesenchymal-to-epithelial transition once CD cells polarize and terminally differentiate. These results may suggest a role for Best1 in renal fibrosis and tissue repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.