ArticleThe Journal of clinical endocrinology and metabolism2009
Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Approach to the patient: investigation of postmenopausal androgen excess.The Journal of clinical endocrinology and metabolism · 2026Review
- The Sex Hormone Precursors Dehydroepiandrosterone (DHEA) and Its Sulfate Ester Form (DHEAS): Molecular Mechanisms and Actions on Human Body.International journal of molecular sciences · 2025Review
- Review
- Physiologic and psychosocial changes of the menopause transition in US Latinas: a narrative review.Climacteric : the journal of the International Menopause Society · 2021Review
- The Effects ofFrontiers in pharmacology · 2021Article
- From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset.Endocrine connections · 2020Article
- The association between abuse history in childhood and salivary rhythms of cortisol and DHEA in postmenopausal women.Psychoneuroendocrinology · 2020Article
- Article
- Management of the Perimenopause.Clinical obstetrics and gynecology · 2018Review
- Association between changes in oestradiol and follicle-stimulating hormone levels during the menopausal transition and risk of diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2017Article
- Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression.Genes, brain, and behavior · 2017Article
- Changes in androstenedione, dehydroepiandrosterone, testosterone, estradiol, and estrone over the menopausal transition.Women's midlife health · 2017Article
- The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers.Frontiers in pharmacology · 2017Review
- Why primate models matter.American journal of primatology · 2014Review
- Ovarian adrenal interactions during the menopausal transition.Minerva ginecologica · 2013Article
- Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women.American journal of physical anthropology · 2013Article
- Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys.Neurobiology of aging · 2013Article
- Association of serum dehydroepiandrosterone sulfate and cognition in older adults: sex steroid, inflammatory, and metabolic mechanisms.Neuropsychology · 2013Article
- Modulation of higher-primate adrenal androgen secretion with estrogen-alone or estrogen-plus-progesterone intervention.Menopause (New York, N.Y.) · 2013Article
- Dehydroepiandrosterone sulfate levels reflect endogenous luteinizing hormone production and response to human chorionic gonadotropin challenge in older female macaque (Macaca fascicularis).Menopause (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
contextA previous report from the Study of Women Across the Nation indicated a rise in dehydroepiandrosterone sulfate (DHEAS) during the menopausal transition using data from three annual visits.
objectiveOur objective was to examine changes in DHEAS with chronological and ovarian aging, expanding the original analyses to include 10 yr of annual data.
designA longitudinal observational study and cross-sectional analyses of baseline data were conducted. OUTCOME MEASURES AND SUBJECTS: DHEAS, age, menopause status, ethnicity, smoking, weight, and height were assessed in 2886 women from five ethnic groups aged 42-52 yr at entry. Hysterectomy, bilateral oophorectomy, and hormone use were excluded.
resultsCross-sectional analysis at baseline showed a linear decline in circulating log-transformed DHEAS with increasing age for either the entire cohort (2.81% per year) or for individual ethnicities. A similar negative association with baseline age (2.44% decline per year) was seen in longitudinal linear mixed modeling including observations from premenopause through late postmenopause, an additional 0.33% decline/year. In contradistinction, a late-transition rise in DHEAS was detected when the same women were analyzed by ovarian status. The average increase in mean circulating DHEAS level between early and late menopause transition, beyond changes predicted by aging, was 3.95%, followed by an average decline of 3.96% during the late postmenopause. Approximately 84.5% of the women had an estimated within-woman increase in DHEAS from premenopause/early perimenopause to late perimenopause/early postmenopause.
conclusionThese observations underscore differences between cross-sectional and longitudinal studies and the importance of considering ovarian status. Additional investigations regarding adrenal contribution to sex steroids in mid-aged women are warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.