ArticleJournal of cell science2009
A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.WIREs mechanisms of disease · 2022Review
- Genetics Underlying the Interactions between Neural Crest Cells and Eye Development.Journal of developmental biology · 2020Review
- Article
- Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis.Developmental biology · 2017Article
- Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Neural tube closure: cellular, molecular and biomechanical mechanisms.Development (Cambridge, England) · 2017Review
- Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling.Frontiers in neuroanatomy · 2017Review
- Stathmin-like 4 is critical for the maintenance of neural progenitor cells in dorsal midbrain of zebrafish larvae.Scientific reports · 2016Article
- Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.Journal of cell science · 2015Article
- Morphomechanics: transforming tubes into organs.Current opinion in genetics & development · 2014Review
- The role of Zic transcription factors in regulating hindbrain retinoic acid signaling.BMC developmental biology · 2013Article
- Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development.Developmental biology · 2013Article
- Article
- A potential role for differential contractility in early brain development and evolution.Biomechanics and modeling in mechanobiology · 2012Article
- Expression of the zic1, zic2, zic3, and zic4 genes in early chick embryos.BMC research notes · 2010Article
- Apical constriction: a cell shape change that can drive morphogenesis.Developmental biology · 2010Review
- Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II.Developmental biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
During neurulation, vertebrate embryos form a neural tube (NT), the rudiment of the central nervous system. In mammals and birds, a key step in cranial NT morphogenesis is dorsolateral hinge-point (DLHP) bending, which requires an apical actomyosin network. The mechanism of DLHP formation is poorly understood, although several essential genes have been identified, among them Zic2, which encodes a zinc-finger transcription factor. We found that DLHP formation in the zebrafish midbrain also requires actomyosin and Zic function. Given this conservation, we used the zebrafish to study how genes encoding Zic proteins regulate DLHP formation. We demonstrate that the ventral zic2a expression border predicts DLHP position. Using morpholino (MO) knockdown, we show zic2a and zic5 are required for apical F-actin and active myosin II localization and junction integrity. Furthermore, myosin II activity can function upstream of junction integrity during DLHP formation, and canonical Wnt signaling, an activator of zic gene transcription, is necessary for apical active myosin II localization, junction integrity and DLHP formation. We conclude that zic genes act downstream of Wnt signaling to control cytoskeletal organization, and possibly adhesion, during neurulation. This study identifies zic2a and zic5 as crucial players in the genetic network linking patterned gene expression to morphogenetic changes during neurulation, and strengthens the utility of the zebrafish midbrain as a NT morphogenesis model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.