SynthesisAnnals of the rheumatic diseases2010
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population.
Synthesis in Annals of the rheumatic diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- The relationship of PADI4_94 polymorphisms with the morbidity of rheumatoid arthritis in Caucasian and Asian populations: a meta-analysis and system review.Clinical rheumatology · 2018Pooled it
- Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis.Clinical rheumatology · 2016Pooled it
- Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.Arthritis research & therapy · 2012Pooled it
- Associations of PTPN22 and PADI4 polymorphisms with rheumatoid arthritis in ASWAN.BMC rheumatology · 2025Article
- Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population.BMC medical genomics · 2023Article
- SNP inInternational journal of molecular sciences · 2023Article
- The lack of association between PADI4_94 or PADI4_104 polymorphisms and RF, ACPA and anti-PAD4 in patients with rheumatoid arthritis.Scientific reports · 2022Article
- Novel functional polymorphism onSaudi journal of biological sciences · 2022Article
- Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.Clinical rheumatology · 2021Article
- Article
- Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.Clinical and experimental immunology · 2017Article
- Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers.Rheumatology (Oxford, England) · 2016Article
- Article
- Rheumatoid arthritis susceptibility genes: An overview.World journal of orthopedics · 2014Review
- RADB: a database of rheumatoid arthritis-related polymorphisms.Database : the journal of biological databases and curation · 2014Article
- Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.Molecular medicine (Cambridge, Mass.) · 2014Article
- Macrophage migration inhibitory factor (MIF): genetic evidence for participation in early onset and early stage rheumatoid arthritis.Cytokine · 2013Article
- Article
- PADI2 is significantly associated with rheumatoid arthritis.PloS one · 2013Article
- Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening.BMC bioinformatics · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPolymorphisms of the peptidylarginine deiminase type 4 (PADI4) gene confer susceptibility to rheumatoid arthritis (RA) in East Asian people. However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population.
methodsThe PADI4_94 (rs2240340) single nucleotide polymorphism (SNP) was directly genotyped in a cohort of unrelated UK Caucasian patients with RA (n=3732) and population controls (n=3039). Imputed data from the Wellcome Trust Case Control Consortium (WTCCC) was used to investigate the association of PADI4_94 with RA in an independent group of RA cases (n=1859) and controls (n=10 599). A further 56 SNPs spanning the PADI4 gene were investigated for association with RA using data from the WTCCC study.
resultsThe PADI4_94 genotype was not associated with RA in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1.01 (95% CI 0.96 to 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with either shared epitope or PTPN22 was detected. No evidence for association with RA was identified for any of the PADI4 SNPs investigated. Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4_94 genotype and RA in people of European descent (OR 1.06, 95% CI 0.99 to 1.13, p=0.12).
conclusionIn the largest study performed to date, the PADI4 genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.