ArticleMolecular & cellular proteomics : MCP2009
Delineation of a carcinogenic Helicobacter pylori proteome.
Article in Molecular & cellular proteomics : MCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans.The Journal of clinical investigation · 2013Trial
- Assembly and glycosylation ofPNAS nexus · 2026Article
- Significance of bacterial and viral genotypes as a risk factor in driving cancer (Review).Molecular and clinical oncology · 2020Article
- Polymorphism in Toll-Like Receptors andCancers · 2019Article
- Imaging the motility and chemotaxis machineries in Helicobacter pylori by cryo-electron tomography.Journal of bacteriology · 2017Article
- Protein signature characterizingInfectious agents and cancer · 2017Article
- Gene polymorphisms of pathogenicWorld journal of gastroenterology · 2016Review
- Article
- Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer.PloS one · 2016Article
- Role of RNA-interference-induced zinc finger protein 139 suppression in gastric cancer cell sensitivity to chemotherapeutic agents.Oncology letters · 2015Article
- Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach.Cancer research · 2015Article
- Differential proteomics of Helicobacter pylori associated with autoimmune atrophic gastritis.Molecular medicine (Cambridge, Mass.) · 2014Article
- Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Role of energy sensor TlpD of Helicobacter pylori in gerbil colonization and genome analyses after adaptation in the gerbil.Infection and immunity · 2013Article
- Two-dimensional gel electrophoresis in bacterial proteomics.Protein & cell · 2012Review
- Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.Journal of proteome research · 2012Article
- Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.PloS one · 2012Article
- The Helicobacter pylori cag Pathogenicity Island.Methods in molecular biology (Clifton, N.J.) · 2012Review
- The structure of Helicobacter pylori HP0310 reveals an atypical peptidoglycan deacetylase.PloS one · 2011Article
- Helicobacter pylori and gastric cancer: factors that modulate disease risk.Clinical microbiology reviews · 2010Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet only a fraction of infected persons ever develop cancer. The extensive genetic diversity inherent to this pathogen has precluded comprehensive analyses of constituents that mediate carcinogenesis. We previously reported that in vivo adaptation of a non-carcinogenic H. pylori strain endowed the output derivative with the ability to induce adenocarcinoma, providing a unique opportunity to identify proteins selectively expressed by an oncogenic H. pylori strain. Using a global proteomics DIGE/MS approach, a novel missense mutation of the flagellar protein FlaA was identified that affects structure and function of this virulence-related organelle. Among 25 additional differentially abundant proteins, this approach also identified new proteins previously unassociated with gastric cancer, generating a profile of H. pylori proteins to use in vaccine development and for screening persons infected with strains most likely to induce severe disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.