ArticleJournal of neural transmission (Vienna, Austria : 1996)2009
Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease.Biomedicines · 2022Article
- Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain.Molecules (Basel, Switzerland) · 2021Review
- Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers.Translational neurodegeneration · 2020Article
- Physical Exercise Modulates L-DOPA-Regulated Molecular Pathways in the MPTP Mouse Model of Parkinson's Disease.Molecular neurobiology · 2018Article
- Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.Translational psychiatry · 2018Article
- Opioid modulation of cognitive impairment in depression.Progress in brain research · 2018Review
- Computational dissection of human episodic memory reveals mental process-specific genetic profiles.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning.Frontiers in behavioral neuroscience · 2015Article
- Genetics of cognition in epilepsy.Epilepsy & behavior : E&B · 2014Review
- PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain.Biochimica et biophysica acta · 2014Article
- Article
- Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.Translational psychiatry · 2013Article
- Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Polymorphisms of the kappa opioid receptor and prodynorphin genes: HIV risk and HIV natural history.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Dynorphins regulate fear memory: from mice to men.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.Addiction biology · 2011Article
- Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment.Journal of addiction research & therapy · 2011Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive functions show large variation in elderly people and are substantially heritable. Animal studies revealed that dynorphins influence cognition and memory, especially in aged animals. Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe). We found that carriers of the minor alleles of rs1997794 (P < 0.002) and rs910080 (P < 0.005) presented with higher episodic memory scores than homozygote carriers of the major allele. Also, a three marker haplotype including these two SNPs and rs2235751 was associated with better episodic memory scores. Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.