ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2009
Low creatine kinase is associated with a high population incidence of fainting.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Lifetime prevalence and correlates of syncope in five ancestry groups. The HELIUS study.International journal of cardiology. Heart & vasculature · 2022Article
- Creatine kinase as predictor of blood pressure and hypertension. Is it all about body mass index? A follow-up study of 250 patients.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Response to creatine kinase and pressor response to orthostatic tolerance.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Fainting, emancipation and the 'weak and sensitive' sex.The Journal of physiology · 2009Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
objectiveVasoconstrictor capacity, skeletal muscle tone, and renal sodium retention are involved in the pathogenesis of fainting. As muscle contractility and ion transport are highly energy-demanding processes, we hypothesized that a low activity of the energy-generating enzyme creatine kinase (CK) is associated with a higher risk of fainting. The aim of this observational study was to explore the association of vasovagal syncope with low CK.
methodsA random sample of 1,000 subjects aged 34-60 years was drawn from the general population, with 442 subjects eventually included in the study. Data on fainting history were collected with the investigators blinded to participants' CK level. We prepared this report according to the "Strengthening the Reporting of Observational Studies in Epidemiology" (STROBE) statement. The main outcome was the lifetime cumulative incidence of vasovagal syncope in subjects with low versus high-normal serum CK after a 3 days rest.
resultsThe proportion of fainters within the high CK group was 29 out of 130 (22%) versus 121 out of 312 (39%) in the low CK group; a 73% greater occurrence of fainting with low CK (P = 0.0005). This finding was consistent across recurrent fainters, and in men and women.
interpretationLow CK is associated with a 73% higher incidence of fainting in a random population sample. The association is biologically plausible, as CK enhances cardiovascular and skeletal muscle contractility and salt retention. The presented data suggest that low CK activity is a potential new risk factor for vasovagal syncope.
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