ReviewNature reviews. Endocrinology2009
Noninvasive imaging of pancreatic beta cells.
Review in Nature reviews. Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Beta Cell Imaging-From Pre-Clinical Validation to First in Man Testing.International journal of molecular sciences · 2020Review
- Targeting Type 1 Diabetes: Selective Approaches for New Therapies.Biochemistry · 2019Review
- Molecular imaging of β-cells: diabetes and beyond.Advanced drug delivery reviews · 2019Review
- Tri-modal In vivo Imaging of Pancreatic Islets Transplanted Subcutaneously in Mice.Molecular imaging and biology · 2018Article
- Improved Labeling of Pancreatic Islets Using Cationic Magnetoliposomes.Journal of personalized medicine · 2018Article
- Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.Pharmacological reviews · 2016Review
- Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.Journal of medicinal chemistry · 2015Article
- Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese.Journal of diabetes investigation · 2014Article
- Imaging of insulin factory: Is it just imagination or approaching reality?Journal of diabetes investigation · 2012Article
- Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.Nuclear medicine and biology · 2012Article
- Functional imaging of glucose-evoked rat islet activities using transient intrinsic optical signals.Journal of modern optics · 2012Article
- High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets.Diabetes · 2011Article
- Experimental approaches for high-resolution in vivo imaging of islet of Langerhans biology.Current diabetes reports · 2011Review
- Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.Molecular pharmaceutics · 2011Article
- Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells.Optics express · 2011Article
- Near-infrared fluorescent probe for imaging of pancreatic beta cells.Bioconjugate chemistry · 2010Article
- The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker.Diabetologia · 2010Article
- Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution.Journal of biomedical opticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noninvasive imaging and quantification of pancreatic, insulin-producing beta cells has been considered a high-priority field of investigation for the past decade. In the first review on this issue, attention was already paid to various agents for labeling beta cells, including 6-(125)I-D-glucose, (65)Zn, (3)H-glibenclamide, (3)H-mitiglinide, an (125)I-labeled mouse monoclonal antibody against beta-cell surface ganglioside(s), D-(U-(14)C)-glucose and 2-deoxy-2-(18)F-D-glucose to label glycogen accumulated in beta cells in response to sustained hyperglycemia, and, last but not least, an analog of D-mannoheptulose. This Review discusses these methods and further contributions. For instance, emphasis is placed on labeling beta cells with (11)C-dihydrotetrabenazine, which is the most advanced method at present. Attention is also drawn to the latest approaches for noninvasive imaging and functional characterization of pancreatic beta cells. None of these procedures is used in clinical practice yet.
Indexed as
Identifiers
19468290What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.