Evidence map›Paper›PMID 19468281›Full record

SynthesisMolecular psychiatry2010

Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder.

M H Bloch, J McGuire, A Landeros-Weisenberger, J F Leckman, C Pittenger

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 16 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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  13. Assessment and management of treatment-refractory obsessive-compulsive disorder in children.Journal of the American Academy of Child and Adolescent Psychiatry · 2015
    Pooled it
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  20. Venlafaxine extended-release treatment of hoarding disorder.International clinical psychopharmacology · 2014
    Trial

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M H BlochYale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA. Michael.bloch@yale.edu
J McGuire
A Landeros-Weisenberger
J F Leckman
C Pittenger

Funding

TRAINING PROGRAM IN CHILDHOOD NEUROPSYCHIATRIC DISORDERST32MH018268 · NIMH · YALE UNIVERSITY · PI Michael H Bloch, MICHAEL J CROWLEY · 1985 to 2026
$11.0M
Longitudinal Structural MRI Study of Adulthood Outcome in Tourette SyndromeK23MH091240 · NIMH · YALE UNIVERSITY · PI BLOCH, MICHAEL H · 2010 to 2014
$902k
CREB and the molecular underpinnings of habit learningK08MH081190 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2008 to 2012
$897k
Treatment of Tourette's Syndrome & Obsessive-Compulsive DisorderK05MH076273 · NIMH · YALE UNIVERSITY · PI LECKMAN, JAMES F · 2006 to 2010
$642k
Targeting Glutamate in OCD: A Placebo-Controlled, Double-Blind Augmentation TrialR34MH083115 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2009 to 2011
$635k
NIMH NIH HHS K05 MH076273NIMH NIH HHS K05MH076273NIMH NIH HHS K08 MH081190NIMH NIH HHS K23 MH091240NIMH NIH HHS R34 MH083115NIMH NIH HHS T32 MH018268
6 · The paper itself

Abstract

We sought to determine differences in efficacy and tolerability between different doses of selective serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder (OCD) using meta-analysis. We identified 9 studies involving 2268 subjects that were randomized, double-blind placebo-controlled clinical trials that compared multiple, fixed-doses of selective serotonin reuptake inhibitors (SSRIs) to each other and to placebo in the treatment of adults with OCD. Change in Y-BOCS score, proportion of treatment responders, and dropouts (all-cause and due to side-effects) were determined for each included study. Weighted mean difference was used to examine mean change in Y-BOCS score. Pooled absolute risk difference was used to examine dichotomous outcomes. Meta-analysis was performed using a fixed effects model in RevMan 4.2.8. We found that compared with either low or medium doses, higher doses of SSRIs were associated with improved treatment efficacy, using either Y-BOCS score or proportion of treatment responders as an outcome. Dose of SSRIs was not associated with the number of all-cause dropouts. Higher doses of SSRIs were associated with significantly higher proportion of dropouts due to side-effects. These results suggests that higher doses of SSRIs are associated with greater efficacy in the treatment of OCD. This SSRI efficacy pattern stands in contrast to other psychiatric disorders like Major Depressive Disorder. This greater treatment efficacy is somewhat counterbalanced by the greater side-effect burden with higher doses of SSRIs. At present, there are insufficient data to generalize these findings to children or adolescents with OCD.

Indexed as

Analysis of VarianceDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleObsessive-Compulsive DisorderOutcome Assessment, Health CareRandomized Controlled Trials as TopicSelective Serotonin Reuptake InhibitorsSelective Serotonin Reuptake Inhibitors

Identifiers

PMID19468281
PMCPMC2888928

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.