ReviewCurrent opinion in hematology2009
Appropriate sequencing of tyrosine kinase inhibitors in chronic myelogenous leukemia: when to change? A perspective in 2009.
Review in Current opinion in hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Profile of Quizartinib for the Treatment of Adult Patients with Relapsed/Refractory FLT3-ITD-Positive Acute Myeloid Leukemia: Evidence to Date.Cancer management and research · 2020Review
- Article
- Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily.Haematologica · 2011Article
Corrections and comments
- Commented on byMyeloid disease.2009
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewKinase inhibitor therapy options for Philadelphia chromosome positive leukemias have rapidly developed and continue to expand. In 2001, imatinib was approved by the US Food and Drug Administration and revolutionized the treatment of chronic myelogenous leukemia (CML); in 2006 and 2007, approval of dasatinib and nilotinib followed for use in imatinib-resistant or intolerant disease; additional kinase inhibitors continue in development to optimize toxicity and circumvent resistance. Decision-making regarding key questions of initial therapy choice, role of allografting, and changes in therapy remains a fluid discussion; this review aims to give a current perspective. RECENT
findingsImatinib remains a highly effective and well characterized choice for patients with CML in chronic phase; long-term toxicity continues to be assessed, and data surrounding stability of response are quite promising. Dasatinib and nilotinib have proven to be highly effective alternate approaches when imatinib is inadequate or intolerable, yet direct comparison in trials is lacking. Limited clinical and molecular data can aid in decision-making between these agents. SUMMARY: Multiple options exist today for the treatment of Philadelphia chromosome positive leukemias. Careful monitoring of response and categorization based on guidelines, utilization of molecular diagnostics, particularly kinase domain mutation analysis, as well as early review of allograft options, can allow for efficient and optimal management of the chronic phase CML patient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.