ArticleThe Journal of experimental medicine2009
CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
Article in The Journal of experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Role of Donor Unrestricted T Cells (DURTs) in TB Host Defense: Implications for Novel TB Vaccine Development.Vaccines · 2026Review
- CD1-restricted T cells: are unconventional allies the key to future TB vaccines?Frontiers in immunology · 2025Review
- Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngotracheitis virus.Frontiers in immunology · 2024Article
- Development and function of chicken XCR1Frontiers in immunology · 2023Article
- Role of MHC class I pathways inFrontiers in cellular and infection microbiology · 2023Review
- The versatility of the CD1 lipid antigen presentation pathway.Immunology · 2018Review
- CD1: A Singed Cat of the Three Antigen Presentation Systems.Archivum immunologiae et therapiae experimentalis · 2017Review
- Lipopeptides: a novel antigen repertoire presented by major histocompatibility complex class I molecules.Immunology · 2016Review
- Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Role of Group 1 CD1-Restricted T Cells in Infectious Disease.Frontiers in immunology · 2015Review
- Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials.Frontiers in immunology · 2015Review
- Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The CD1 size problem: lipid antigens, ligands, and scaffolds.Cellular and molecular life sciences : CMLS · 2014Review
- The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis.Frontiers in immunology · 2014Review
- Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Diverse antigen presentation by the Group 1 CD1 molecule, CD1c.Molecular immunology · 2013Review
- CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.The Journal of experimental medicine · 2013Article
- Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- HIV-1 Vpu interference with innate cell-mediated immune mechanisms.Current HIV research · 2012Review
- Mycoketide: a CD1c-presented antigen with important implications in mycobacterial infection.Clinical & developmental immunology · 2012Review
Corrections and comments
- Erratum issuedBarral, Duarte [corrected to Barral, Duarte C]
Authors and funding
18 authors at 7 institutions in 1 country.
Funding
Abstract
The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only in mycobacteria, but its discovery raises the possibility that ribosomally produced viral or mammalian proteins that commonly undergo lipidation might also function as antigens. To test this, we measured T cell responses to synthetic acylpeptides that mimic lipoproteins produced by cells and viruses. CD1c presented an N-acyl glycine dodecamer peptide (lipo-12) to human T cells, and the response was specific for the acyl linkage as well as the peptide length and sequence. Thus, CD1c represents the second member of the CD1 family to present lipopeptides. lipo-12 was efficiently recognized when presented by intact cells, and unlike DDM, it was inactivated by proteases and augmented by protease inhibitors. Although lysosomes often promote antigen presentation by CD1, rerouting CD1c to lysosomes by mutating CD1 tail sequences caused reduction in lipo-12 presentation. Thus, although certain antigens require antigen processing in lysosomes, others are destroyed there, providing a hypothesis for the evolutionary conservation of large CD1 families containing isoforms that survey early endosomal pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.