ArticleAtherosclerosis2009
Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries.
Article in Atherosclerosis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging
In Vivo Molecular Imaging (MRI) of Atherothrombotic Lesions
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Molecular imaging of carotid artery atherosclerosis with PET: a systematic review.European journal of nuclear medicine and molecular imaging · 2020Pooled it
- Anti-inflammatory and morphologic effects of pitavastatin on carotid arteries and thoracic aorta evaluated by integrated backscatter trans-esophageal ultrasound and PET/CT: a prospective randomized comparative study with pravastatin (EPICENTRE study).Cardiovascular ultrasound · 2015Trial
- The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis.European journal of nuclear medicine and molecular imaging · 2013Trial
- Rationale and design of dal-PLAQUE: a study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography.American heart journal · 2011Trial
- PET Imaging of Carotid Atherosclerosis: Methodology, Implications, and Applications in Neurovascular Disease.Stroke · 2026Review
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- The Role of HSP47 in Thrombotic Disorders: Molecular Mechanism and Therapeutic Potential.Current issues in molecular biology · 2025Review
- Diagnostic Methods of Atherosclerotic Plaque and the Assessment of Its Prognostic Significance-A Narrative Review.Journal of cardiovascular development and disease · 2024Review
- Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease.Frontiers in cardiovascular medicine · 2024Article
- Multi-Modality Imaging of Atheromatous Plaques in Peripheral Arterial Disease: Integrating Molecular and Imaging Markers.International journal of molecular sciences · 2023Review
- PET/MR imaging of inflammation in atherosclerosis.Nature biomedical engineering · 2023Review
- Positron emission tomography and its role in the assessment of vulnerable plaques in comparison to other imaging modalities.Frontiers in medicine · 2023Review
- Scan-rescan measurement repeatability ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Alzheimer's Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects-Atherosclerosis for a Start.Journal of Alzheimer's disease : JAD · 2022Article
- Time-resolved Fluorescence Immunoassay (TRFIA) for the Simultaneous Detection of MMP-9 and Lp-PLA2 in Serum.Journal of fluorescence · 2021Article
- Metabolic regulation of macrophage proliferation and function in atherosclerosis.Current opinion in lipidology · 2021Review
- Article
- Integrated cardiovascular assessment of atherosclerosis using PET/MRI.The British journal of radiology · 2020Review
- Should vascular wallThe international journal of cardiovascular imaging · 2020Article
- Trained Immunity: An Underlying Driver of Inflammatory Atherosclerosis.Frontiers in immunology · 2020Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the relationship between atherosclerotic plaque inflammation, as assessed by FDG-positron emission tomography/computed tomography (FDG-PET/CT), and plaque morphology and composition, as assessed by magnetic resonance imaging (MRI), in the carotid and femoral arteries. MATERIALS AND
methodsSixteen patients underwent FDG-PET/CT and MRI (T2-weighted (T2W) and proton density weighted (PDW)) of the carotid and femoral arteries. For every image slice, two observers determined the corresponding regions of the FDG-PET/CT and MRI image sets by matching CT and T2W axial images. Each plaque was then classified into one of three groups according to the CT appearance and T2W/PDW signal: (1) collagen, (2) lipid-necrotic core and (3) calcium. Arterial FDG uptake was measured for each plaque and normalized to vein FDG activity to produce a blood-normalized artery activity called the target to background ratio (TBR). The vessel wall thickness (VWT), the vessel wall area and the total vessel wall area were measured from the T2W MR images.
resultsThe TBR value was higher in the lipid-necrotic core group compared to the collagen and calcium groups, (p<0.001). The lipid-necrotic core group demonstrated a significant TBR variation according to the median of the VWT (TBR=1.26+/-0.25 vs. 1.50+/-0.12). There was no correlation with other morphological MR parameters.
conclusionsThis study demonstrates the complementary value of non-invasive FDG-PET/CT and MR imaging for the evaluation of atherosclerotic plaque composition and activity. Lipid-rich plaques are more inflamed than either calcified or collagen-rich plaques.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.