ArticleHeart rhythm2009
Instability in action potential morphology underlies phase 2 reentry: a mathematical modeling study.
Article in Heart rhythm, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Phase 2 Re-Entry Without IJACC. Clinical electrophysiology · 2023Trial
- Arrhythmogenic Manifestations of Chagas Disease: Perspectives From the Bench to Bedside.Circulation research · 2024Review
- Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024Review
- Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases.Physical review. E · 2024Article
- Diffuse fibrosis and repolarization disorders explain ventricular arrhythmias in Brugada syndrome: a computational study.Scientific reports · 2022Article
- Why Is Only Type 1 Electrocardiogram Diagnostic of Brugada Syndrome? Mechanistic Insights From Computer Modeling.Circulation. Arrhythmia and electrophysiology · 2022Article
- Pinocembrin Decreases Atrial Fibrillation Susceptibility in a Rodent Model of Depression.Frontiers in cardiovascular medicine · 2022Article
- Life and death saddles in the heart.Physical review. E · 2021Article
- Mechanisms of Premature Ventricular Complexes Caused by QT Prolongation.Biophysical journal · 2021Article
- Stability of spatially discordant repolarization alternans in cardiac tissue.Chaos (Woodbury, N.Y.) · 2020Article
- Spatially Discordant Repolarization Alternans in the Absence of Conduction Velocity Restitution.Biophysical journal · 2020Article
- Concomitant SK current activation and sodium current inhibition cause J wave syndrome.JCI insight · 2018Article
- Memory-induced nonlinear dynamics of excitation in cardiac diseases.Physical review. E · 2018Article
- Memory-Induced Chaos in Cardiac Excitation.Physical review letters · 2017Article
- Cardiac dynamics: Alternans and arrhythmogenesis.Journal of arrhythmia · 2016Review
- All-optical control of cardiac excitation: combined high-resolution optogenetic actuation and optical mapping.The Journal of physiology · 2016Review
- Perspective: a dynamics-based classification of ventricular arrhythmias.Journal of molecular and cellular cardiology · 2015Review
- Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome.BioMed research international · 2015Article
- Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence.Annual review of physiology · 2015Review
- Nonlinear and Stochastic Dynamics in the Heart.Physics reports · 2014Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhase 2 reentry occurs when electrotonic current propagates from sites of normal notch-and-dome action potentials (APs) to loss-of-dome abbreviated AP sites, causing abnormal reexcitation. The existence of two neighboring regions exhibiting these two different AP morphologies is believed to be sufficient for local reexcitation and development of phase 2 reentry.
objectiveThe purpose of this study was to investigate the mechanism of phase 2 reentry development in simulated tissues having no gradient or continuous gradients of ionic currents that affect phase 2. In particular, we investigated gradients of the transient outward current conductance G(to), representing hypothesized right ventricular G(to) gradients.
methodsSingle-cell simulations of Luo-Rudy dynamic model cells with a range of G(to) values were performed. In addition, one-dimensional fiber simulations were used to investigate the spatiotemporal phenomenon of phase 2 reentry.
resultsIn single-cell simulations, low and normal values of G(to) produced the notch-and-dome morphology, whereas high values of G(to) produced abbreviated APs with loss-of-dome morphology. However, intermediate values of G(to) caused cells to switch intermittently between the two morphologies during constant pacing. Phase 2 reentry occurred in homogeneous and heterogeneous cable simulations, but only when a mass of cells had G(to) values close to the unstable "switching" behavior range.
conclusionA main factor underlying phase 2 reentry apparently is not the presence of two different stable morphologies in adjacent regions but rather unstable switching AP morphology within a significant subset of cells.
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Registered trials
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