ArticleHeart rhythm2009
Transmural optical measurements of Vm dynamics during long-duration ventricular fibrillation in canine hearts.
Article in Heart rhythm, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time.Heart international · 2026Review
- ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology.Scientific reports · 2019Article
- Mechanism of reentry induction by a 9-V battery in rabbit ventricles.American journal of physiology. Heart and circulatory physiology · 2014Article
- Does the combination of hyperkalemia and KATP activation determine excitation rate gradient and electrical failure in the globally ischemic fibrillating heart?American journal of physiology. Heart and circulatory physiology · 2013Article
- Properties of blebbistatin for cardiac optical mapping and other imaging applications.Pflugers Archiv : European journal of physiology · 2012Article
- Role of KATP channel in electrical depression and asystole during long-duration ventricular fibrillation in ex vivo canine heart.American journal of physiology. Heart and circulatory physiology · 2012Article
- Intramural optical mapping of V(m) and Ca(i)2+ during long-duration ventricular fibrillation in canine hearts.American journal of physiology. Heart and circulatory physiology · 2012Article
- The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime.American journal of physiology. Heart and circulatory physiology · 2012Article
- Mapping of cardiac electrical activation with electromechanical wave imaging: an in silico-in vivo reciprocity study.Heart rhythm · 2011Article
- Complex structure of electrophysiological gradients emerging during long-duration ventricular fibrillation in the canine heart.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundKnowledge of transmural V(m) changes is important for understanding the mechanism of long-duration ventricular fibrillation (LDVF).
objectiveThe purpose of this study was to measure transmural V(m) changes during LDVF.
methodsV(m) was recorded optically at up to 8 transmural points separated by 1.5 mm in the left ventricle of Langendorff-perfused canine hearts (n = 6) using a bundle of optical fibers (optrode) during 10 minutes of LDVF followed by 3 minutes of VF with reperfusion. Measurements were grouped into 4 layers: epicardium, subepicardium, midwall, and subendocardium.
resultsActivation rates (ARs) and action potential durations (APDs) decreased, whereas diastolic intervals (DIs) increased during LDVF in all transmural layers (P < .05). After approximately 3 minutes of LDVF, ARs were faster and DIs shorter in the midwall and subendocardium than in the epicardium and subepicardium (P < .05). Activations persisted at the subendocardium but disappeared from other layers after approximately 8 minutes of VF in the majority of hearts. There were no transmural differences in APD during LDVF or during pacing before and after LDVF (P > .05). Restitution plots showed no functional relationship between APD and DI in any layer at any stage of LDVF. Partial reperfusion during VF for 3 minutes restored transmural synchronicity of activation and eliminated gradients in activation parameters.
conclusionV(m) dynamics evolve differently at different transmural layers. The subendocardium maintains persistent and the fastest activation during 10 minutes of LDVF, suggesting it contains the source of VF wavefronts. There are no transmural APD gradients and no restitution relationship between APD and DI at any transmural layer, indicating these are not the primary factors in the mechanism of LDVF.
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