ArticleNeurobiology of disease2009
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials.
Article in Neurobiology of disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.The American journal of psychiatry · 2018Trial
- Aberrant Fear: Biological Underpinnings Relevant to Psychosis, Antipsychotic Drugs, and Psychotherapeutic Treatments, a Translational Approach.International journal of molecular sciences · 2026Review
- Rapid-Onset Therapeutic Effects of Delta Opioid Receptor Agonists on Depression-Like Behaviors Induced by Chronic Social Defeat Stress.Neuropsychopharmacology reports · 2025Article
- Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- N-methyl-D-aspartate receptor antagonism impairs sensory gating in the auditory cortex in response to speech stimuli.Psychopharmacology · 2022Article
- Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain.Physiological research · 2022Article
- C57BL/6N mice show a sub-strain specific resistance to the psychotomimetic effects of ketamine.Frontiers in behavioral neuroscience · 2022Article
- Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms in Male Albino Rats.Brain sciences · 2021Article
- The influence of ketamine's repeated treatment on brain topology does not suggest an antidepressant efficacy.Translational psychiatry · 2020Article
- The effect of ketamine on the consolidation and extinction of contextual fear memory.Journal of psychopharmacology (Oxford, England) · 2018Article
- The Combination of Long-term Ketamine and Extinction Training Contributes to Fear Erasure by Bdnf Methylation.Frontiers in cellular neuroscience · 2017Article
- Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine.Neuropharmacology · 2016Article
- Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice.Drug and alcohol dependence · 2015Article
- Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis.Biological psychiatry · 2015Review
- Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice.Drug and alcohol dependence · 2014Article
- How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia.Antioxidants & redox signaling · 2013Review
- The electrophysiological signature of motivational salience in mice and implications for schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Deficits in emotional learning and memory in an animal model of schizophrenia.Behavioural brain research · 2012Article
- NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia.Neurobiology of disease · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever. Despite its value in the clinical setting, little is known about the immediate and long-lasting effects of repeated ketamine treatment. We assessed the effects of chronic administration of a subanesthetic dose of ketamine on contextual fear conditioning, detection of pitch deviants and auditory gating. After four, but not two, weeks of daily ketamine injections, mice exhibited decreased freezing in the fear conditioning paradigm. Gating of the P80 component of auditory evoked potentials was also significantly altered by treatment condition, as ketamine caused a significant decrease in S1 amplitude. Additionally, P20 latency was significantly increased as a result of ketamine treatment. Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.