ReviewMolecular and cellular biochemistry2009
Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart.
Review in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Extremely High Systemic Immune Inflammation Levels Increase the Risk of All-Cause and Cardiovascular Mortality in Postmenopausal Women.International journal of women's health · 2025Article
- Article
- Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells.International journal of molecular sciences · 2024Article
- Article
- Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies.Cardiovascular diabetology · 2018Review
- Endocrine Disruptors Leading to Obesity and Related Diseases.International journal of environmental research and public health · 2017Review
- PPARPPAR research · 2017Review
- Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies.Current diabetes reviews · 2016Review
- Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus.Cardiovascular & hematological agents in medicinal chemistry · 2016Review
- Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria.PloS one · 2015Article
- Di-peptidyl peptidase-4 inhibitor sitagliptin protects vascular function in metabolic syndrome: possible role of epigenetic regulation.Molecular biology reports · 2014Article
- FMLP-, thapsigargin-, and H₂O₂-evoked changes in intracellular free calcium concentration in lymphocytes and neutrophils of type 2 diabetic patients.Molecular and cellular biochemistry · 2014Article
- Structural changes in the myocardium during diabetes-induced cardiomyopathy.Heart failure reviews · 2014Review
- Impaired retinal vasodilator responses in prediabetes and type 2 diabetes.Acta ophthalmologica · 2013Article
- Myocardial Perfusion SPECT Utility in Predicting Cardiovascular Events Among Indonesian Diabetic Patients.The open cardiovascular medicine journal · 2013Article
- Alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly Zucker diabetic fatty rat heart.International journal of molecular sciences · 2012Article
- PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty.Journal of lipid research · 2012Review
- The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects.Journal of diabetes and metabolic disorders · 2012Article
- [Update on diabetic macroangiopathy].Der Pathologe · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developing coronary macroangiopathy in diabetes remains incompletely characterized. Various biochemical mechanisms speculated to being at the "heart" of diabetic cardiac and coronary macroangiopathy are reviewed in the present article. In doing so, this article presents evidence that the labyrinthine interactions of hyperglycemia, insulin resistance, and dyslipidemia in diabetes result in a pro-atherogenic phenotype. Furthermore, the diabetic milieu yields a complex (dys)metabolic environment characterized by chronic inflammation, procoagulability, impaired fibrinolysis, neovascularization abnormalities, and microvascular defects that cumulatively alter blood rheology, artery structure, and homeostasis of the endothelium. The contributory influences of these factors in the pathophysiology of coronary artery disease in diabetes are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.