ArticleHeart and vessels2009
Favorable cardiac and aortic remodeling in olmesartan-treated spontaneously hypertensive rats.
Article in Heart and vessels, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Ultrasound assessment of tensile stress in carotid arteries of healthy human subjects with varying age.BMC medical imaging · 2019Trial
- Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients.Heart and vessels · 2011Trial
- Protective Effect of Esmolol on the Hypertensive Aortic Wall Persists After Withdrawal of Short-Term Treatment.Journal of clinical medicine · 2026Article
- HDL attenuates Ang II-AT1R-EGFR signaling and reverses vascular remodeling in spontaneously hypertensive rats.Frontiers in pharmacology · 2025Article
- Complexation of the Antihypertensive Drug Olmesartan with Zn: In Vivo Antihypertensive and Cardiac Effects.Biological trace element research · 2024Article
- Article
- Effects of Captopril and Losartan on Cardiac Stereology in Rats with Renovascular Hypertension.Iranian journal of medical sciences · 2021Article
- Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats.Scientific reports · 2020Article
- Does gender influence cardiovascular remodeling in C57BL/6J mice fed a high-fat, high-sucrose and high-salt diet?International journal of experimental pathology · 2019Review
- Article
- Chronic exercise impairs nitric oxide pathway in rabbit carotid and femoral arteries.The Journal of physiology · 2018Article
- Vascular Protective Effects ofInternational journal of vascular medicine · 2018Article
- The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Aortic remodelling in chronic nicotine-administered rat.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Article
- Effects of Losartan and Amlodipine on Left Ventricular Remodeling and Function in Young Stroke-Prone Spontaneously Hypertensive Rats.Acta Cardiologica Sinica · 2014Article
- The role of repeatedly heated soybean oil in the development of hypertension in rats: association with vascular inflammation.International journal of experimental pathology · 2012Article
- Involvement of inflammation and adverse vascular remodelling in the blood pressure raising effect of repeatedly heated palm oil in rats.International journal of vascular medicine · 2012Article
- Combined effects of irbesartan and carvedilol on expression of tissue factor and tissue factor pathway inhibitor in rats after myocardial infarction.Heart and vessels · 2011Article
- Cell membrane stretch activates intermediate-conductance Ca2+-activated K+ channels in arterial smooth muscle cells.Heart and vessels · 2011Article
- The nonpeptide AVE0991 attenuates myocardial hypertrophy as induced by angiotensin II through downregulation of transforming growth factor-beta1/Smad2 expression.Heart and vessels · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular remodeling contributes to the progression of cardiovascular disease. Thus, our aim was to evaluate the action of long-term treatment with olmesartan on cardiac and aortic adverse remodeling and its relationship with blood pressure (BP) and tensile forces acting on the aortic wall. Five-month-old male rats were divided in: WKY group (n = 6), SHR group (n = 6), and SHRs treated with hydralazine 30 mg/kg/day (SHR-H, n = 8) or olmesartan 10 mg/kg/day (SHR-O, n = 8). Medications were administered for 16 weeks. The SHR group showed hypertension (189 +/- 4 mmHg), cardiomyocyte hypertrophy (+107%), interstitial fibrosis (5.7% vs 1.9% in WKY), and reduced intramyocardial vascularization (9.1% vs 22.8% in WKY). In aorta, the SHRs showed outward hypertrophic remodeling, increased elastic fibers content (+36%), and increased circumferential wall tension (CWT, 2.79 x 10(4) dyne/cm) and tensile stress (TS, 261.4 x 10(4) dyne/cm(2)). Hydralazine and olmesartan decreased BP (-45% approximately) and likewise CWT and TS (-45% and -35% approximately). Both medications prevented left ventricle remodeling, but olmesartan improved cardiomyocyte hypertrophy better than hydralazine. Hydralazine did not alter media hypertrophy, but it enlarged lumen diameter and increased elastic fibers. It is unlikely that olmesartan prevented all aortic alterations. Taken together, long-term control of BP alone is not sufficient to prevent aortic remodeling due to hypertension, but in myocardium it seems to be enough, except for cardiomyocyte hypertrophy. The differential action of olmesartan suggests that it is essential to block growth stimulation by angiotensin II in cardiomyocytes and vascular smooth muscle cells in order to better prevent cardiovascular adverse remodeling due to arterial hypertension.
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Registered trials
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