ArticleHeart and vessels2009
Matrix metalloproteinase-1 and -2 levels are differently regulated in acute exacerbation of heart failure in patients with and without left ventricular systolic dysfunction.
Article in Heart and vessels, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril.Heart and vessels · 2010Trial
- Biological variation of extracellular matrix biomarkers in patients with stable chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Observational
- Circulating matrix metalloproteinase patterns in association with aortic dilatation in bicuspid aortic valve patients with isolated severe aortic stenosis.Heart and vessels · 2016Article
- High serum levels of thrombospondin-2 correlate with poor prognosis of patients with heart failure with preserved ejection fraction.Heart and vessels · 2016Article
- Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity.BMC medical genetics · 2013Article
- Dilatation of the ascending aorta and serum alpha 1-antitrypsin level in patients with bicuspid aortic valve.Heart and vessels · 2012Article
- Novel cardiac-specific biomarkers and the cardiovascular continuum.Biomarker insights · 2012Article
- Administration of angiotensin-converting enzyme inhibitors is associated with slow progression of mild aortic stenosis in Japanese patients.Heart and vessels · 2011Article
- Force-frequency relationship as a predictor of long-term prognosis in patients with heart diseases.Heart and vessels · 2011Article
- Cytokines and matrix metalloproteinases as potential biomarkers in chronic heart failure.Biomarkers in medicine · 2009Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMPs) play important roles in progression of chronic heart failure (HF) by regulating cardiac extracellular matrix metabolism. However, there is no report to investigate the difference of circulating MMP-1 and MMP-2 levels between systolic HF (SHF) and diastolic HF (DHF), particularly in light of acute exacerbation of HF. We assessed 110 HF patients who were admitted because of an acute exacerbation. They were divided into two groups: SHF [n = 68, left ventricular ejection fraction (LVEF) <45%] or DHF (n = 42, LVEF > or =45%). Ten patients without HF served as controls. Serum MMP-1 and MMP-2, and plasma brain natriuretic peptide (BNP) levels were examined on admission and at discharge. Serum MMP-1 level was higher on admission in both SHF and DHF than in controls. It was higher in SHF than in DHF and did not change at discharge in both groups. Serum MMP-2 level was equally higher on admission in SHF and DHF than in controls. It decreased in both groups at discharge. Treatment-induced changes in LVEF and BNP level correlated with those in MMP-2 level in SHF but not in DHF. Circulating MMP-1 and MMP-2 levels showed different dynamics between SHF and DHF in acute exacerbation and after treatment. These differences in circulating MMP-1 and MMP-2 levels may be related to the phenotype of HF.
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