ArticleAmerican journal of epidemiology2009
Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort.
Article in American journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Effects of different sleep disorders on frailty in the elderly: a systematic review and meta-analysis of observational studies.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Sleep and frailty risk: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Association Between Wrist-Worn Device-Estimated Sleep Efficiency and Hand Grip Strength in Older Outpatients With Cardiometabolic Diseases: Cross-Sectional Study.JMIR formative research · 2026Article
- OSA in the aging population: Diagnostic and therapeutic considerations.Sleep medicine reviews · 2026Review
- The connection between depression and frailty among older adults with obstructive sleep apnea: results from a multicenter cohort study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Role of subjective snoring in dementia risk.Sleep · 2025Article
- Causality between sleep traits and the risk of frailty: a Mendelian randomization study.Frontiers in public health · 2024Article
- Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study.BMC geriatrics · 2023Article
- Frailty Syndrome Is Associated with Poorer Self-Reported Sleep Quality Among Older Persons with Human Immunodeficiency Virus.AIDS research and human retroviruses · 2022Article
- Association between risk of obstructive sleep apnea and cognitive performance, frailty, and quality of life among older adults with atrial fibrillation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Association of sleep disturbances with sarcopenia and its defining components: the ELSA-Brasil study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction.Frontiers in neuroscience · 2021Review
- Sex Differences in the Association Between Risk of Obstructive Sleep Apnea, Insomnia, and Frailty in Older Adults.Nature and science of sleep · 2021Article
- Frailty and Sleep Disorder in Chronic Liver Diseases.Life (Basel, Switzerland) · 2020Article
- Long and Short Sleep Duration and Physical Frailty in Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2018Article
- Effects of exercise and weight loss in older adults with obstructive sleep apnea.Medicine and science in sports and exercise · 2015Article
- Sleep in older adults: normative changes, sleep disorders, and treatment options.Clinics in geriatric medicine · 2014Review
- Sleep disturbance in older ICU patients.Clinical interventions in aging · 2014Review
- Measures of frailty in population-based studies: an overview.BMC geriatrics · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Sleep-disordered breathing (SDB) is associated with pathophysiology that may influence the development and progression of frailty. Using data collected in 1995-1996, the authors explored the relation between SDB and components of frailty among 1,042 participants of the Cardiovascular Health Study. Diagnosis of SDB was based on the results of overnight polysomnography, and severe SDB was defined as an apnea-hypopnea index of >30 per hour of sleep. Slow walking speed, low grip strength, exhaustion, low physical activity, and unexplained weight loss were referred to as frailty indicator variables. There were 584 (56%) female and 458 (44%) male participants, and the mean age was 77 (standard deviation, 4) years. There was independent association between severe SDB and 1 or more frailty indicator variables (adjusted odds ratio = 4.85, 95% confidence interval: 1.40, 16.78), slow walking speed (adjusted odds ratio = 2.67, 95% confidence interval: 1.04, 6.84), and low grip strength (adjusted odds ratio = 3.29, 95% confidence interval: 1.36, 7.96) among female study participants. The finding of an independent association between SDB and frailty indicator variables among older women could have important implications in interventions aimed at preventing or delaying the progression of frailty.
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Registered trials
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