ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2009
No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04522752 (Long-term Endoscopic Follow-up of Benign Epithelial Gastric Polyps), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Endoscopic Follow-up of Benign Epithelial Gastric Polyps: a Multicenter Prospective Large Sample Cohort Study
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Clinical significance of colonoscopy in patients with upper gastrointestinal polyps and neoplasms: a meta-analysis.PloS one · 2014Pooled it
- Article
- Gastric adenocarcinoma with submucosal invasion occurs in a sporadic fundic gland polyp of a Helicobacter pylori-uninfected patient on proton pump inhibitor.Clinical journal of gastroenterology · 2025Article
- Sporadic Fundic Gland Polyposis Associated With Long-Term Proton Pump Inhibitor Use: A Case Report.Cureus · 2025Article
- Vonoprazan: A Review in Erosive Esophagitis and Non-Erosive Gastro-Esophageal Reflux Disease.Drugs · 2025Review
- Gastric Polyps Detected Incidentally during Gastroscopy and Follow-Up Results.Journal of clinical medicine · 2024Article
- Clinicopathologic Correlation of Large Gastric Polyps in an Elderly Female: Case Report and Review of the Literature.Cureus · 2024Article
- Region-specific Wnt signaling responses promote gastric polyp formation in patients with familial adenomatous polyposis.JCI insight · 2023Article
- Relationship between endoscopic gastric abnormalities and colorectal polyps: a cross-sectional study based on 33439 Chinese patients.International journal of medical sciences · 2023Article
- Image-enhanced endoscopy for real-time differentiation between hyperplastic and fundic gland polyps in the stomach.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- The Potential Value of Gastric Histopathology for Predicting Colorectal Adenomatous Polyps Among the Chinese Population: A Retrospective Cross-Sectional Study.Frontiers in oncology · 2022Article
- Sporadic fundic gland polyps with dysplasia or carcinoma: Clinical and endoscopic characteristics.World journal of gastrointestinal oncology · 2021Review
- Gastritis, Gastric Polyps and Gastric Cancer.International journal of molecular sciences · 2021Review
- Development of a narrow-band imaging classification to reduce the need for routine biopsies of gastric polyps.Gastroenterology report · 2021Article
- Two Asian families with gastric adenocarcinoma and proximal polyposis of the stomach successfully treated via laparoscopic total gastrectomy.Clinical journal of gastroenterology · 2021Article
- Prevalence of Endoscopic Findings Before Bariatric Surgery and Their Influence on the Selection of the Surgical Technique.Obesity surgery · 2020Article
- A case of gastric adenocarcinoma considered to originate from a sporadic fundic gland polyp in a Helicobacter pylori-uninfected stomach.Clinical journal of gastroenterology · 2020Article
- Upper Gastrointestinal Disease Influences the Occurrence of Inflammatory Bowel Disease.Digestive diseases and sciences · 2020Article
- Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management.Journal of gastrointestinal oncology · 2019Article
- Gastric Xanthomas and Fundic Gland Polyps as Endoscopic Risk Indicators of Gastric Cancer.Gut and liver · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsFundic gland polyps (FGPs), the most common type of gastric polyps, have been associated with prolonged proton pump inhibitor therapy and an increased risk of colon cancer. The presence of FGPs has been inversely correlated with Helicobacter pylori infection. We evaluated the prevalence of H pylori-associated gastritis, colonic polyps, and carcinomas in subjects with and without FGPs.
methodsWe analyzed data collected from community-based endoscopy centers in 36 states (plus Washington DC and Puerto Rico) on patients who underwent esophagogastroduodenoscopy (EGD) and colonoscopy between April 2007 and March 2008. Of the 103,385 patients who underwent EGD during this time period, gastric biopsy samples were collected from 78,801 and colonic biopsies from 26,017. Slides of samples from Helicobacter-infected FGPs and FGPs with dysplasia were reviewed.
resultsFGPs were detected in 6081 patients (67.8% women). Helicobacter infection was present in less than 0.5% patients with FGPs and 13.0% of those without FGPs (odds ratio [OR], 29.05; 95% confidence interval [CI], 20.4-41.4; P < .0001). Colonic adenomas were detected in 42.3% of women with FGPs and 33.8% of those without (OR, 1.43; 95% CI, 1.26-1.63; P < .001); there was no significant difference in colonic adenomas between men with and without FGPs.
conclusionsWomen had a higher prevalence of FGPs. FGPs were associated with gastroesophageal reflux disease symptoms, gastric heterotopia, hyperplastic colonic polyps (only in men), and colonic adenomas (only in women, especially those over 60 years of age). The presence of FGPs was inversely correlated with H pylori infection, active gastritis, and gastric neoplasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.