ArticleMolecular and biochemical parasitology2009
A complex of three related membrane proteins is conserved on malarial merozoites.
Article in Molecular and biochemical parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
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- Targeting SUMOylation inFrontiers in cellular and infection microbiology · 2021Review
- Apicomplexan lineage-specific polytopic membrane proteins inJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Membrane Protein Production and Purification from Escherichia coli and Sf9 Insect Cells.Methods in molecular biology (Clifton, N.J.) · 2020Article
- An essential contractile ring protein controls cell division in Plasmodium falciparum.Nature communications · 2019Article
- The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold.The Journal of biological chemistry · 2014Article
- The inner membrane complex through development of Toxoplasma gondii and Plasmodium.Cellular microbiology · 2014Review
- The alveolin IMC1h is required for normal ookinete and sporozoite motility behaviour and host colonisation in Plasmodium berghei.PloS one · 2012Article
- Detecting mutations in PfCRT and PfMDR1 genes among Plasmodium falciparum isolates from Saudi Arabia by pyrosequencing.Parasitology research · 2011Article
- A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division.PLoS pathogens · 2010Article
- Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum.Nature biotechnology · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Invasion of human red blood cells by the malaria parasite Plasmodium falciparum is a coordinated, multi-step process. Here, we describe three novel integral membrane proteins that colocalize on the inner membrane complex immediately beneath the merozoite plasma membrane. Each has six predicted transmembrane domains and is conserved in diverse apicomplexan parasites. Immunoprecipitation studies using specific antibodies reveal that these proteins assemble into a heteromeric complex. Each protein was also expressed on insect cells using the baculovirus vector system with a truncated SUMO tag that facilitates maximal expression and protein purification while permitting cleavage with SUMO protease to release unmodified parasite protein. The expressed proteins were successfully reconstituted into artificial liposomes, but were not recognized by human immune sera. Because all three genes are highly conserved in apicomplexan parasites, the complex formed by their encoded proteins likely serves an essential role for invasive merozoites.
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