ArticleNeurotoxicology2009
Analysis of PCB congeners related to cognitive functioning in adolescents.
Article in Neurotoxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Mixture Effects of Polychlorinated Biphenyls (PCBs) and Three Organochlorine Pesticides on Cognitive Function in Mohawk Adults at Akwesasne.International journal of environmental research and public health · 2023Article
- An evidence map of polychlorinated biphenyl exposure and health outcome studies among residents of the Akwesasne Mohawk Nation.Chemosphere · 2022Review
- Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review).International journal of molecular medicine · 2021Review
- Biomarkers of metabolic disorders and neurobehavioral diseases in a PCB- exposed population: What we learned and the implications for future research.Environmental research · 2020Review
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- Neurotoxicity of polychlorinated biphenyls and related organohalogens.Acta neuropathologica · 2019Review
- Prenatal dioxin exposure and neuropsychological functioning in the Seveso Second Generation Health Study.International journal of hygiene and environmental health · 2019Article
- Outdoor Air Emissions, Land Use, and Land Cover around Schools on Tribal Lands.International journal of environmental research and public health · 2018Article
- Review of built and natural environment stressors impacting American-Indian/Alaska-Native children.Reviews on environmental health · 2018Review
- Ambient Air Exposure to PCBs: Regulation and Monitoring at Five Contaminated Sites in EPA Regions 1, 2, 4, and 5.New solutions : a journal of environmental and occupational health policy : NS · 2018Article
- Early Life Exposure to Low Levels of AHR Agonist PCB126 (3,3',4,4',5-Pentachlorobiphenyl) Reprograms Gene Expression in Adult Brain.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- PCBs and measures of attention and impulsivity on a continuous performance task of young adults.Neurotoxicology and teratology · 2017Article
- Changes in persistent organic pollutant levels from adolescence to young adulthood.Environmental research · 2015Article
- Maternal lifestyle and environmental risk factors for autism spectrum disorders.International journal of epidemiology · 2014Review
- Cultural and health implications of fish advisories in a Native American community.Ecological processes · 2013Article
- The physical environment and child development: an international review.International journal of psychology : Journal international de psychologie · 2013Review
- Indigenous peoples of North America: environmental exposures and reproductive justice.Environmental health perspectives · 2012Article
- Growth as a mirror: is endocrine disruption challenging Tanner's concept?Annals of human biology · 2012Article
- Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities.Environment international · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
To investigate the characteristics of PCBs that are linked to cognitive functioning, those congeners that were concurrently found in 271 Mohawk adolescents were grouped according to structure (dioxin-like or non-dioxin-like) and persistence (persistent or low-persistent). After the effects of the congener groups were orthogonalized, regression analyses (controlling for a number of variables found to be related to the cognitive outcomes) examined the relationship of each congener group to scores on three cognitive tests (the non-verbal Ravens Progressive Matrices, the Test of Memory and Learning, and the Woodcock Johnson-Revised). Five subtests from these cognitive tests were found to be associated with one or more PCB congener groups, most often at a moderate level. Two measures of long-term memory (Delayed Recall and Long Term Retrieval) were associated with all four congener groups. Nevertheless, examination of the role of individual congeners in the significantly related congener groups revealed that almost all congeners associated with cognitive outcomes were non-dioxin-like and ortho-substituted. A notable exception was the Ravens test where scores were associated only with dioxin-like congeners. This finding adds to the limited evidence of neurotoxic effects of dioxin-like congeners. Auditory Processing was related only to the persistent congener group. The association of the non-persistent congener group with three cognitive test scores (Delayed Recall, Long Term Retrieval and Comprehension-Knowledge) suggests that the Mohawk adolescents have experienced continuing or recent environmental exposure to PCBs that is sufficient to result in detectable cognitive decrements. Comparison of our findings with those of other human studies was limited by the relative lack of specificity of both PCB measures and cognitive outcome measures in much previous work.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.