ReviewLife sciences2010
Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?
Review in Life sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- The World of GPCR dimers - Mapping dopamine receptor DComputational and structural biotechnology journal · 2023Article
- Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.Journal of medicinal chemistry · 2021Article
- Current Concepts and Treatments of Schizophrenia.Molecules (Basel, Switzerland) · 2018Review
- An engineered opsin monomer scrambles phospholipids.Scientific reports · 2017Article
- The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics.Journal of molecular modeling · 2016Article
- Preferred supramolecular organization and dimer interfaces of opioid receptors from simulated self-association.PLoS computational biology · 2015Article
- Communication over the network of binary switches regulates the activation of A2A adenosine receptor.PLoS computational biology · 2015Article
- Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via Gαq-mediated mechanism.Journal of cellular and molecular medicine · 2014Article
- GPCRsort-responding to the next generation sequencing data challenge: prediction of G protein-coupled receptor classes using only structural region lengths.Omics : a journal of integrative biology · 2014Article
- Application of in utero electroporation of G-protein coupled receptor (GPCR) genes, for subcellular localization of hardly identifiable GPCR in mouse cerebral cortex.Molecules and cells · 2014Article
- Opioid receptors: toward separation of analgesic from undesirable effects.Trends in biochemical sciences · 2013Review
- Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.Molecular pharmacology · 2013Article
- Fractal dimension as a measure of surface roughness of G protein-coupled receptors: implications for structure and function.Journal of molecular modeling · 2012Article
- Assessing the relative stability of dimer interfaces in g protein-coupled receptors.PLoS computational biology · 2012Article
- Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.The Journal of biological chemistry · 2011Article
- Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function.Progress in lipid research · 2011Review
- Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors.Biochemistry · 2011Article
- Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.Science (New York, N.Y.) · 2010Article
- Oligomeric forms of G protein-coupled receptors (GPCRs).Trends in biochemical sciences · 2010Article
- On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.Journal of receptor and signal transduction research · 2010Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
For years, conventional drug design at G-protein coupled receptors (GPCRs) has mainly focused on the inhibition of a single receptor at a usually well-defined ligand-binding site. The recent discovery of more and more physiologically relevant GPCR dimers/oligomers suggests that selectively targeting these complexes or designing small molecules that inhibit receptor-receptor interactions might provide new opportunities for novel drug discovery. To uncover the fundamental mechanisms and dynamics governing GPCR dimerization/oligomerization, it is crucial to understand the dynamic process of receptor-receptor association, and to identify regions that are suitable for selective drug binding. This minireview highlights current progress in the development of increasingly accurate dynamic molecular models of GPCR oligomers based on structural, biochemical, and biophysical information that has recently appeared in the literature. In view of this new information, there has never been a more exciting time for computational research into GPCRs than at present. Information-driven modern molecular models of GPCR complexes are expected to efficiently guide the rational design of GPCR oligomer-specific drugs, possibly allowing researchers to reach for the high-hanging fruits in GPCR drug discovery, i.e. more potent and selective drugs for efficient therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.