ArticlePhytomedicine : international journal of phytotherapy and phytopharmacology2009
Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats.
Article in Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343767 (A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus), which is not on this map. Cited by 23 papers.
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The trial behind it
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A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus
Who cites it
23 citing papers in PubMed, 98 citations in OpenAlex.
- Physiological and transcriptomic analysis reveal the regulation of adventitious root formation in Cinnamomum parthenoxylon cuttings.BMC plant biology · 2024Article
- Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus.Animal models and experimental medicine · 2024Review
- Amelioration of hyperglycemia and hyperlipidemia in a high-fat diet-fed mice by supplementation of a developed optimized polyherbal formulation.3 Biotech · 2022Article
- Review
- A Phase II, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of NW Low-Glu® in Patients Newly Diagnosed with Type 2 Diabetes Mellitus.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- An immunohistochemical examination of cinnamon extract administration on distribution of NGF (nerve growth factor) and Trk-A (tyrosine kinase-A) receptor for diabetic rats with pancreatic tissue.Turkish journal of medical sciences · 2021Article
- High anti-inflammatory and antidiabetic activities ofJournal of diabetes and metabolic disorders · 2021Article
- Review
- Hypoglycemic, Anti-Hyperglycemic and Anti-Hyperlipidemic Effects ofJournal of experimental pharmacology · 2020Article
- Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins.Molecules (Basel, Switzerland) · 2018Article
- Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols.Journal of diabetes research · 2017Review
- Improved Lipid Profile Associated with Daily Consumption of Tri-Sura-Phon in Healthy Overweight Volunteers: An Open-Label, Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.Natural products and bioprospecting · 2016Article
- Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro.Acta pharmacologica Sinica · 2016Article
- Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying.Scientific reports · 2015Article
- Evaluation of the in vitro anti-hyperglycemic effect of Cinnamomum cassia derived phenolic phytochemicals, via carbohydrate hydrolyzing enzyme inhibition.Plant foods for human nutrition (Dordrecht, Netherlands) · 2014Article
- Cinnamon: a multifaceted medicinal plant.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Anti-Diabetic Activities of Jiaotaiwan in db/db Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Antidiabetic activities of ethanolic extract and fraction of Anthocleista djalonensis.Asian Pacific journal of tropical biomedicine · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cinnamon bark has been reported to be effective in the alleviation of diabetes through its antioxidant and insulin-potentiating activities. The water-soluble polyphenolic oligomers found in cinnamon are thought to be responsible for this biological activity. In this study, the hypoglycemic activity of a polyphenolic oligomer-rich extract from the barks of Cinnamomum parthenoxylon (Jack) Nees was studied in normal, transiently hyperglycemic, and streptozotocin (STZ)-induced diabetic rats. Oral administration of the extract at doses of 100, 200, and 300 mg/kg body wt. caused significant changes in body weight loss and fasting blood glucose levels of normal rats. In STZ-induced diabetic rats, after administration of the extract at doses of 100, 200, and 300 mg/kg body wt. over 14 days, the blood glucose levels were decreased by 11.1%, 22.5%, and 38.7%, respectively, and the plasma insulin levels were significantly increased over pre-treatment levels. In an oral glucose tolerance test, the extract produced a significant decrease in glycemia 90 min after the glucose pulse. These results suggest that Cinnamomum parthenoxylon polyphenolic oligomer-rich extract could be potentially useful for post-prandial hyperglycemia treatment.
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