ArticleNeurobiology of disease2009
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons.
Article in Neurobiology of disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons.Biology open · 2019Article
- HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein.Nucleic acids research · 2018Article
- Splice form-dependent regulation of axonal arbor complexity by FMRP.Developmental neurobiology · 2017Article
- Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.Human molecular genetics · 2017Article
- A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function.EMBO molecular medicine · 2015Article
- N-myristoylation regulates the axonal distribution of the Fragile X-related protein FXR2P.Molecular and cellular neurosciences · 2014Article
- The pur protein family: genetic and structural features in development and disease.Journal of cellular physiology · 2013Review
- A new regulatory function of the region proximal to the RGG box in the fragile X mental retardation protein.Journal of cell science · 2011Article
- CGG repeat in the FMR1 gene: size matters.Clinical genetics · 2011Review
- FMR1 premutation and full mutation molecular mechanisms related to autism.Journal of neurodevelopmental disorders · 2011Article
- Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15).PloS one · 2011Article
- Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.PloS one · 2011Article
- Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines. We examined the role of functional domains of FMRP in neuronal RNA-granule formation and dendritic transport using different FMRP variants, including the mutant FMRP_I304N and the splice-variant FMRP_Iso12. Both variants are absent from dendritic RNA-granules in Fmr1 knockout neurons. Co-transfection experiments showed that wild-type FMRP recruits both FMRP variants into dendritic RNA-granules. Co-transfection of FXR2, an FMRP homologue, also resulted in redistribution of both variants into dendritic RNA-granules. Furthermore, the capacity of the variants to transport their mRNAs and the mRNA localization of an FMR1 construct containing silent point-mutations affecting only the G-quartet-structure were investigated. In conclusion, we show that wild-type FMRP and FXR2P are able to recruit FMRP variants into RNA-granules and that the G-quartet-structure in FMR1 mRNA is not essential for its incorporation in RNA-granules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.