ArticleProceedings of the National Academy of Sciences of the United States of America1991
Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 121 citations in OpenAlex.
- Article
- The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside.Biomarker research · 2024Review
- Molecular mechanism for kinesin-1 direct membrane recognition.Science advances · 2021Article
- Engagement of Neurotropic Viruses in Fast Axonal Transport: Mechanisms, Potential Role of Host Kinases and Implications for Neuronal Dysfunction.Frontiers in cellular neuroscience · 2021Article
- Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Molecular neurobiology · 2018Review
- Review
- Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases.Neurobiology of disease · 2017Review
- Drive the Car(go)s-New Modalities to Control Cargo Trafficking in Live Cells.Frontiers in molecular neuroscience · 2017Review
- A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 in Leukocyte Transendothelial Migration.The American journal of pathology · 2016Article
- Altered expression of KLC3 may affect semen parameters.International journal of reproductive biomedicine · 2016Article
- A Naturally Occurring Repeat Protein with High Internal Sequence Identity Defines a New Class of TPR-like Proteins.Structure (London, England : 1993) · 2015Article
- Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.Experimental brain research · 2012Review
- Kinesins at a glance.Journal of cell science · 2010Article
- No conventional function for the conventional kinesin?Traffic (Copenhagen, Denmark) · 2008Article
- Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.Biochemistry · 2008Article
- Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.Molecular biology of the cell · 2007Article
- Novel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains.BMC genomics · 2006Article
- A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons.The EMBO journal · 2004Article
- Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.The Journal of biological chemistry · 2003Article
- Fast axonal transport misregulation and Alzheimer's disease.Neuromolecular medicine · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Movement of membrane-bounded organelles to intracellular destinations requires properly oriented microtubules and force-generating enzymes, such as the microtubule-stimulated ATPase kinesin. Kinesin is a heterotetramer with two heavy chain (approximately 124-kDa) and two light chain (approximately 64-kDa) subunits. Kinesin heavy chains contain both ATP- and microtubule-binding domains and are capable of force generation in vitro. Functions of the light chains are undetermined, although evidence suggests they interact with membrane surfaces. We have used molecular genetic approaches to dissect the kinesin light chain structure. Three distinct kinesin light chain cDNAs were cloned and sequenced from rat brain, and they were found to result from alternative splicing of a single gene. Polypeptides encoded by these cDNAs are identical except for their carboxyl ends. Synthesis of multiple light chains, differing from one another in primary structure, could provide a means of generating multiple, functionally specialized forms of the kinesin holoenzyme.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.