ArticleInternational journal for parasitology2009
Genetic structure of Schistosoma mansoni in western Kenya: The effects of geography and host sharing
Article in International journal for parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Schistosome species, parasite development, and co-infection combinations determine microbiome dynamics in the snail Biomphalaria glabrata.Animal microbiome · 2025Article
- Evidence of high genetic diversity among parasite populations in a schistosomiasis hotspot.Microbiology spectrum · 2025Article
- Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration.Nature communications · 2021Article
- Schistosomiasis Morbidity Hotspots: Roles of the Human Host, the Parasite and Their Interface in the Development of Severe Morbidity.Frontiers in immunology · 2021Review
- Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda.Parasites & vectors · 2019Article
- Population Structure and Dynamics of Helminthic Infection: Schistosomiasis.Microbiology spectrum · 2019Review
- The effect of sample size on estimates of genetic differentiation and effective population size for Schistosoma mansoni populations.International journal for parasitology · 2018Article
- Article
- Relative compatibility of Schistosoma mansoni with Biomphalaria sudanica and B. pfeifferi from Kenya as assessed by PCR amplification of the S. mansoni ND5 gene in conjunction with traditional methods.Parasites & vectors · 2016Article
- Digenean-gastropod host associations inform on aspects of specific immunity in snails.Developmental and comparative immunology · 2015Review
- No apparent reduction in schistosome burden or genetic diversity following four years of school-based mass drug administration in mwea, central kenya, a heavy transmission area.PLoS neglected tropical diseases · 2014Article
- Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?Heredity · 2014Article
- This de-wormed world?The Journal of parasitology · 2013Article
- Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.BMC immunology · 2013Article
- Non-invasive sampling of schistosomes from humans requires correcting for family structure.PLoS neglected tropical diseases · 2013Article
- Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections.PLoS neglected tropical diseases · 2013Article
- High prevalence of schistosomiasis in Mbita and its adjacent islands of Lake Victoria, western Kenya.Parasites & vectors · 2012Article
- Genetic population structure of cercariae from an urban foci of Schistosoma mansoni, Brazil.The American journal of tropical medicine and hygiene · 2012Article
- Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.International journal for parasitology · 2011Article
- Applying evolutionary genetics to schistosome epidemiology.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2010Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We examined the spatial structure of Schistosoma mansoni, a parasite of humans, from natural infections at two levels: across the Lake Victoria basin of Kenya and among snail hosts. Using 20 microsatellite markers we examined geographic patterns of relatedness and population structure of cercariae and found weak, but significant structure detected by some, but not all analyses. We hypothesise structure created by aggregations of clonal individuals or adherence of hosts to local transmission sites is eroded by high amounts of gene flow in the region. This finding also supports previous hypotheses concerning the evolution of drug resistance in the region. Intrasnail dynamics were investigated in the context of aggregation and kin selection theory to determine how relatedness and also sex influence host sharing and host exploitation. Cercarial production did not differ significantly between snails with one or two genotypes suggesting that mixed infections resulted in decreased individual fitness and provides a framework for reproductive competition. Coinfection patterns in snails were independent of parasite relatedness indicating that schistosomes were not aggregated according to their relatedness and that kin selection was not influencing host sharing. Additionally, host exploitation in coinfections (measured by cercarial production) was not negatively correlated with relatedness, as predicted by classical models due to increased competition and thus exploitation when parasites are unrelated. Because of the low levels of relatedness within the population, schistosomes may rarely encounter close relatives and kin selection mechanisms that influence the distribution of individuals within snails or the virulence mode of the parasites may simply have not evolved.
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