ArticleVirology2009
Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Advancements in veterinary medicine: the use of Flowgy for nasal airflow simulation and surgical predictions in big felids (a case study in lions).Frontiers in veterinary science · 2023Article
- Equal contributions of feline immunodeficiency virus and coinfections to morbidity in African lions.International journal for parasitology. Parasites and wildlife · 2021Article
- Cross-species transmission of retroviruses among domestic and wild felids in human-occupied landscapes in Chile.Evolutionary applications · 2021Article
- Management of Suspected Cases of Feline Immunodeficiency Virus Infection in Eurasian Lynx (Frontiers in veterinary science · 2021Article
- African Lions and Zoonotic Diseases: Implications for Commercial Lion Farms in South Africa.Animals : an open access journal from MDPI · 2020Review
- Feline immunodeficiency virus in puma: Estimation of force of infection reveals insights into transmission.Ecology and evolution · 2019Article
- Feline Immunodeficiency Virus Cross-Species Transmission: Implications for Emergence of New Lentiviral Infections.Journal of virology · 2017Article
- Infection and cancer in multicellular organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Gammaretrovirus-specific antibodies in free-ranging and captive Namibian cheetahs.Clinical and vaccine immunology : CVI · 2015Article
- Rapid evolution of the env gene leader sequence in cats naturally infected with feline immunodeficiency virus.The Journal of general virology · 2015Article
- Article
- Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.Immunogenetics · 2013Article
- A simple model explains the dynamics of preferential host switching among mammal RNA viruses.Evolution; international journal of organic evolution · 2013Article
- Assessing the impact of feline immunodeficiency virus and bovine tuberculosis co-infection in African lions.Proceedings. Biological sciences · 2012Article
- Feline immunodeficiency virus in South America.Viruses · 2012Review
- Emerging viruses in the Felidae: shifting paradigms.Viruses · 2012Review
- Three pathogens in sympatric populations of pumas, bobcats, and domestic cats: implications for infectious disease transmission.PloS one · 2012Article
- Review
- FIV diversity: FIV Ple subtype composition may influence disease outcome in African lions.Veterinary immunology and immunopathology · 2011Article
- Retroviral restriction and dependency factors in primates and carnivores.Veterinary immunology and immunopathology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Feline immunodeficiency virus (FIV) causes AIDS in the domestic cat (Felis catus) but has not been explicitly associated with AIDS pathology in any of the eight free-ranging species of Felidae that are endemic with circulating FIV strains. African lion (Panthera leo) populations are infected with lion-specific FIV strains (FIVple), yet there remains uncertainty about the degree to which FIV infection impacts their health. Reported CD4+ T-lymphocyte depletion in FIVple-infected lions and anecdotal reports of lion morbidity associated with FIV seroprevalence emphasize the concern as to whether FIVple is innocuous or pathogenic. Here we monitored clinical, biochemical, histological and serological parameters among FIVple-positive (N=47) as compared to FIVple-negative (N=17) lions anesthetized and sampled on multiple occasions between 1999 and 2006 in Botswana. Relative to uninfected lions, FIVple-infected lions displayed a significant elevation in the prevalence of AIDS-defining conditions: lymphadenopathy, gingivitis, tongue papillomas, dehydration, and poor coat condition, as well as displaying abnormal red blood cell parameters, depressed serum albumin, and elevated liver enzymes and gamma globulin. Spleen and lymph node biopsies from free-ranging FIVple-infected lions (N=9) revealed evidence of lymphoid depletion, the hallmark pathology documented in immunodeficiency virus infections of humans (HIV-1), macaques, and domestic cats. We conclude that over time FIVple infections in free-ranging lions can lead to adverse clinical, immunological, and pathological outcomes in some individuals that parallel sequelae caused by lentivirus infection in humans (HIV), Asian macaques (SIV) and domestic cats (FIVfca).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.