ReviewPeptides2009
Electrophysiological effects of MCH on neurons in the hypothalamus.
Review in Peptides, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hypothalamic MCH Neurons: From Feeding to Cognitive Control.Function (Oxford, England) · 2024Review
- Control of energy homeostasis by the lateral hypothalamic area.Trends in neurosciences · 2023Review
- Fast neurotransmitter identity of MCH neurons: Do contents depend on context?Frontiers in neuroendocrinology · 2023Review
- Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation.Veterinary sciences · 2023Article
- Article
- Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity.Nature neuroscience · 2022Article
- Article
- The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation.Frontiers in neuroscience · 2020Review
- New insight into GABAergic neurons in the hypothalamic feeding regulation.The journal of physiological sciences : JPS · 2018Review
- The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep.The Journal of physiology · 2016Review
- Melanin-concentrating hormone neurons release glutamate for feedforward inhibition of the lateral septum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression.Frontiers in neuroscience · 2015Review
- Histamine inhibits the melanin-concentrating hormone system: implications for sleep and arousal.The Journal of physiology · 2014Article
- The role of melanin-concentrating hormone and its receptors in energy homeostasis.Frontiers in endocrinology · 2013Article
- Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Experience-dependent plasticity in hypocretin/orexin neurones: re-setting arousal threshold.Acta physiologica (Oxford, England) · 2010Review
- Integrating GHS into the Ghrelin System.International journal of peptides · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Melanin concentrating hormone (MCH) has been implicated in many brain functions and behaviors essential to the survival of animals. The hypothalamus is one of the primary targets where MCH-containing nerve fibers and MCH receptors are extensively expressed and its actions in the brain are exerted. Since the identification of MCH receptors as orphan G protein coupled receptors, the cellular effects of MCH have been revealed in many non-neuronal expression systems (including Xenopus oocytes and cell lines), however, the mechanism by which MCH modulates the activity in the neuronal circuitry of the brain is still under investigation. This review summarizes our current knowledge of electrophysiological effects of MCH on neurons in the hypothalamus, particularly in the lateral hypothalamus. Generally, MCH exerts inhibitory effects on neurons in this structure and may serve as a homeostatic regulator in the lateral hypothalamic area. Given the contrast between the limited data on cellular functions of MCH in the hypothalamus versus a fast growing body of evidence on the vital role of MCH in animal behavior, further investigations of the former are warranted.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.